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Table 2 Antibody responses compared with negative control sera and in relation to time since infection, past infection and parasitaemia

From: Antibodies elicited in adults by a primary Plasmodium falciparum blood-stage infection recognize different epitopes compared with immune individuals

Median optical density

MSP119

MSP2 3D7

MSP2 FC27

MSP2 3D7 non-repetitive

MSP2 FC27 non-repetitive

MSP2 conserved region

MSP4

MSP5

MSP6B

MSP7B

RAMA-E

Overall (n = 55)

1.273a

0.296a

0.285a

0.939a

0.456a

0.291a

0.578a

0.35a

0.099a

0.295a

0.091a

0–2 weeks (n = 21)

2.95a

0.421a

0.681a

1.095a

0.635a

0.362ac

0.885a

0.407a

0.141ac

0.582a

0.089a

4–8 weeks (n = 11)

1.65ad

0.538a

0.511a

1.841ad

0.597ad

0.344ad

0.694a

0.412ad

0.154ad

0.295a

0.192ad

10–41 weeks (n = 23)

0.46a

0.137a

0.151a

0.497a

0.23a

0.146a

0.415a

0.292a

0.047a

0.25a

0.057a

No past infection (n = 37)

0.681ae

0.157a

0.229a

0.849a

0.413a

0.32a

0.61a

0.24af

0.068a

0.284a

0.089a

Past infection (n = 18)

2.82a

0.975a

0.748a

1.098a

0.598a

0.274a

0.463a

0.402a

0.121a

0.404a

0.114a

Lower quartile parasitaemia (n = 14)

0.252a

0.101a

0.08b

0.656a

0.18bg

0.221b

0.419b

0.335b

0.043b

0.285b

0.075b

Upper quartile parasitaemia (n = 14)

0.83a

0.157a

0.428a

0.684a

0.645a

0.525a

0.708b

0.198b

0.069a

0.176a

0.071a

Negative control (n = 30)

-.004

0.009

0.015

0.061

0.044

0.069

0.086

0.074

0.010

0.055

0.013

  1. a differs from neg controls p < 0.0001
  2. b differs from neg controls p < 0.05
  3. c Timepoint 1 vs timepoint 3 median difference p < 0.05
  4. d Timepoint 2 vs timepoint 3 median difference p < 0.05
  5. e No past infection vs past infection median difference p < 0.05
  6. f No past infection vs past infection median difference p < 0.01
  7. g Lower vs upper quartile parasitaemia median difference p < 0.05