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Table 2 Effects of IPT-SP, pyrimethamine or no chemoprophylactic agent on malaria parasitaemia and pregnancy outcomes in parturient women in southwestern Nigeria

From: Intermittent preventive treatment with sulphadoxine-pyrimethamine is effective in preventing maternal and placental malaria in Ibadan, south-western Nigeria

Outcome measure IPT-SP Pyrimethamine No Chemoprophylaxis P value
  N = 598 N = 214 N = 171  
  n (%) n (%) n (%)  
Maternal parasitemia 62 (10.4%) 34 (15.9) 29 (17.0) 0.021
Placental parasitemia 63 (10.5%) 36 (16.8) 29 (17.0) 0.015
Cord parasitemia 16 (2.7%) 9 (4.2) 9 (5.3) 0.210
Neonatal parasitemia 4 (0.7%) 3 (1.4) 1 (0.6) 0.553
Maternal haematocrit(%)     
Mean ± SD 36.48 ± 4.55 36. 39 ± 4.7 35.17 ± 5.58 0.006
Range 18 – 45 20 – 45 17 – 45  
Maternal anaemia     
(Haematocrit <30%) 33/579 (5.7%) 19 (8.9) 26 (15.4) <0.0001
Pre-term delivery     
(Gestational age <37 weeks) 63 (10.5%) 41 (19.2) 43 (25.3) <0.0001
Neonatal birth weight(gm)     
Mean ± SD 3204.3 ± 487.2 3075.7 ± 513.24 3074.7 ± 505.9 <0.0001
Range 1500 – 4700 1300 – 4500 1400 – 4500  
Low birth weight(%) 31/595 (5.2) 17 (7.9) 16 (9.4) 0.095
Neonatal haematocrit(%)     
Mean ± SD 58.2 ± 7.8 57.1 ± 7.66 56.8 ± 8.0 0.041
Range 35 – 79 34 – 75 31 – 75  
Placental weight(gm)     
Mean 605.54 ± SD 605.5 ± 113.6 607.7 ± 131.9 588.9 ± 136. 0.253