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Figure 2 | Malaria Journal

Figure 2

From: Co-infection with Trypanosoma cruzi protects mice against early death by neurological or pulmonary disorders induced by Plasmodium berghei ANKA

Figure 2

Breakdown of blood brain barrier in mice infected with P. berghei ANKA or co-infected with T. cruzi. C57BL/6 mice were separated in 4 groups, two of which were inoculated with T. cruzi G strain. Fifteen days later, one uninfected (n = 5) and one T. cruzi-infected group (n = 5) were inoculated with P. berghei ANKA, whereas one group remained uninfected (n = 3). When P. berghei-infected mice showed signs of neurological disorder, they were given the Evans blue and 1 h later the brain was removed. At this time, the corresponding number of mice in other groups received the dye and the brain was collected 1 h later. Note the difference of brain color in the three groups. The brains of the group with single T. cruzi infection (n = 5) (not shown) were indistinguishable from the normal mice.

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