place of study/endemicity

Northern Uganda intense holoendemic

Mali/intense seasonal

Nigeria/holoendemic

Viet Nam/ND

Gabon/hyperendemic

population

children, 6–59 months old

children, 3 months to 14 years old

children

adults

children, 6 months to 14 years old

study size

(n = 208), severe (n = 99)/uncomplicated (n = 99)

(n = 516), severe (n = 163), uncomplicated (n = 163), healthy (n = 164)

(n = 146), cerebral (n = 43), uncomplicated (n = 43), asymptomatic (n = 32), no malaria (n = 28)

(n = 300), cerebral (n = 168), fatal (n = 40)

(n = 73), severe (n = 42), mild (n = 31)

WBC count method

assuming 8,000/μL

assuming 7,500/μL

assuming 8,000/μL

assuming 8,000/μL

ND

Hzleucocyte counting method

thin film/counting 500 leukocytes

thin films/counting 30 monocytes, 100 PCN

thick films/counting 30 monocytes, 100 PCN

thin & thick films/counting 30 monocytes, 100 PCN

thick films/counting 100 monocytes, 100 PCN

quality assessment of microscopy

ND

10% of slides reexamined by 2nd micoscopist

ND

3 slides observed by 10 microscopists/1 slide examined 10× times by the same microscopist

count independently by two investigators

Result of quality assessment

ND

Kappa coefficient for: – PMN: 0,88 – mono: 0,77

ND

mono: 125, 76 and 40

ND
