|
place of study/endemicity
|
Northern Uganda intense holoendemic
|
Mali/intense seasonal
|
Nigeria/holoendemic
|
Viet Nam/ND
|
Gabon/hyperendemic
|
|
population
|
children, 6–59 months old
|
children, 3 months to 14 years old
|
children
|
adults
|
children, 6 months to 14 years old
|
|
study size
|
(n = 208), severe (n = 99)/uncomplicated (n = 99)
|
(n = 516), severe (n = 163), uncomplicated (n = 163), healthy (n = 164)
|
(n = 146), cerebral (n = 43), uncomplicated (n = 43), asymptomatic (n = 32), no malaria (n = 28)
|
(n = 300), cerebral (n = 168), fatal (n = 40)
|
(n = 73), severe (n = 42), mild (n = 31)
|
|
WBC count method
|
assuming 8,000/μL
|
assuming 7,500/μL
|
assuming 8,000/μL
|
assuming 8,000/μL
|
ND
|
|
Hz-leucocyte counting method
|
thin film/counting 500 leukocytes
|
thin films/counting 30 monocytes, 100 PCN
|
thick films/counting 30 monocytes, 100 PCN
|
thin & thick films/counting 30 monocytes, 100 PCN
|
thick films/counting 100 monocytes, 100 PCN
|
|
quality assessment of microscopy
|
ND
|
10% of slides re-examined by 2nd micoscopist
|
ND
|
3 slides observed by 10 microscopists/1 slide examined 10× times by the same microscopist
|
count independently by two investigators
|
|
Result of quality assessment
|
ND
|
Kappa coefficient for: – PMN: 0,88 – mono: 0,77
|
ND
|
-mono: 125, 76 and 40
|
ND
|
