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Table 4 Selected studies investigating Hz-containing leukocytes and disease severity

From: Full blood count and haemozoin-containing leukocytes in children with malaria: diagnostic value and association with disease severity

Reference year published Mujuzi et al. 2006 [32] Lyke et al. 2003 [9] Amodu et al. 1998 [8] Phu et al. 1995 [31] Metzger et al. 1995 [7]
place of study/endemicity Northern Uganda intense holoendemic Mali/intense seasonal Nigeria/holoendemic Viet Nam/ND Gabon/hyperendemic
population children, 6–59 months old children, 3 months to 14 years old children adults children, 6 months to 14 years old
study size (n = 208), severe (n = 99)/uncomplicated (n = 99) (n = 516), severe (n = 163), uncomplicated (n = 163), healthy (n = 164) (n = 146), cerebral (n = 43), uncomplicated (n = 43), asymptomatic (n = 32), no malaria (n = 28) (n = 300), cerebral (n = 168), fatal (n = 40) (n = 73), severe (n = 42), mild (n = 31)
WBC count method assuming 8,000/μL assuming 7,500/μL assuming 8,000/μL assuming 8,000/μL ND
Hz-leucocyte counting method thin film/counting 500 leukocytes thin films/counting 30 monocytes, 100 PCN thick films/counting 30 monocytes, 100 PCN thin & thick films/counting 30 monocytes, 100 PCN thick films/counting 100 monocytes, 100 PCN
quality assessment of microscopy ND 10% of slides re-examined by 2nd micoscopist ND 3 slides observed by 10 microscopists/1 slide examined 10× times by the same microscopist count independently by two investigators
Result of quality assessment ND Kappa coefficient for: – PMN: 0,88 – mono: 0,77 ND -mono: 125, 76 and 40 ND
  1. ND: not determined/done or not given