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Table 2 The prevalence of single nucleotide polymorphisms (SNP) at codon 51, 59 and 108 of Pfdhfr and codon 436/437 and 540 of Pfdhps in the two cross sectional surveys

From: Rapid increase of Plasmodium falciparum dhfr/dhps resistant haplotypes, after the adoption of sulphadoxine-pyrimethamine as first line treatment in 2002, in southern Mozambique

Pfdhfr codon

Cross1

Cross2

P

  

N

(%)

N

(%)

 

51

N

43

32.3

33

27.8

0.169

 

I

49

36.8

58

46.0

0.507

 

Mixed (N/I)

41

30.8

33

26.2

 

59

C

16

12.7

14

11.0

0.853

 

R

66

52.4

69

54.3

0.828

 

Mixed (C/R)

44

87.3

44

34.6

 

108

S

14

11.0

8

6.2

0.080

 

N

64

50.4

80

62.0

0.249

 

Mixed (S/N)

49

38.6

41

31.8

 

Pfdhps codon

N

(%)

N

(%)

 

436/437

AA

3

2.4

1

0.8

0.746

 

SA

50

39.7

37

29.8

0.007

 

SG

15

11.9

35

28.2

0.063

 

Mixed

     
 

AA/SA

2

1.6

1

0.8

 
 

SA/SG

56

44.4

45

36.3

 
 

AA/SA/SG

0

0

5

4.0

 

540

K

80

63.5

73

54.5

< 0.001

 

E

10

7.9

38

28.4

0.117

 

Mixed (K/E)

36

28.6

23

17.2

 
  1. The data are given as total numbers and as percentages and including genotype infections where the identification of SNP/haplotypes for a few samples were not complete. Mixed: Prevalence of infections with mixed SNP for each codon. P: P-values of χ2-tests of prevalence comparisons between the two cross sectional surveys where the prevalence of infections of each SNP including mixed infections are set against prevalence of infections without the particular SNP.