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Table 2 The prevalence of single nucleotide polymorphisms (SNP) at codon 51, 59 and 108 of Pfdhfr and codon 436/437 and 540 of Pfdhps in the two cross sectional surveys

From: Rapid increase of Plasmodium falciparum dhfr/dhps resistant haplotypes, after the adoption of sulphadoxine-pyrimethamine as first line treatment in 2002, in southern Mozambique

Pfdhfr codon Cross1 Cross2 P
   N (%) N (%)  
51 N 43 32.3 33 27.8 0.169
  I 49 36.8 58 46.0 0.507
  Mixed (N/I) 41 30.8 33 26.2  
59 C 16 12.7 14 11.0 0.853
  R 66 52.4 69 54.3 0.828
  Mixed (C/R) 44 87.3 44 34.6  
108 S 14 11.0 8 6.2 0.080
  N 64 50.4 80 62.0 0.249
  Mixed (S/N) 49 38.6 41 31.8  
Pfdhps codon N (%) N (%)  
436/437 AA 3 2.4 1 0.8 0.746
  SA 50 39.7 37 29.8 0.007
  SG 15 11.9 35 28.2 0.063
  Mixed      
  AA/SA 2 1.6 1 0.8  
  SA/SG 56 44.4 45 36.3  
  AA/SA/SG 0 0 5 4.0  
540 K 80 63.5 73 54.5 < 0.001
  E 10 7.9 38 28.4 0.117
  Mixed (K/E) 36 28.6 23 17.2  
  1. The data are given as total numbers and as percentages and including genotype infections where the identification of SNP/haplotypes for a few samples were not complete. Mixed: Prevalence of infections with mixed SNP for each codon. P: P-values of χ2-tests of prevalence comparisons between the two cross sectional surveys where the prevalence of infections of each SNP including mixed infections are set against prevalence of infections without the particular SNP.