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Table 1 Developmental expression of surf genes as seen by RT-PCR using primer set 1. surf genes exhibit a differential expression pattern during the different stages of the parasite cycle.

From: SURFIN4.1, a schizont-merozoite associated protein in the SURFIN family of Plasmodium falciparum

surf Gene

 

Time Post Invasion (hrs)

SURFIN Grouping§

 

PlasmoDB ID

10

20

30

40

 

surf 1.1

PFA0625w

-

-

+

+

A

surf 1.2

PFA0650w

-

-

-

-

Truncated

surf 1.3

PFA0725w

+

+

+

+

B

surf 4.1

PFD0105c, PFD0100c

-

-

+

+

A

surf 4.2

PFD1160w

+

+

+

+

A

surf 8.1

MAL8P1.1

-

-

-

-

B

surf 8.2

PF08_0002

-

-

-

-

A

surf 8.3

MAL8P1.162

+

+

+

+

B

surf 13.1

PF13_0074, PF13_0075

-

-

-

-

Truncated

surf 14.1

PF14_0747

-

-

+

-

B

  1. The genes that are expressed are indicated by "+" while those that are not expressed are indicated by "-". surf4.1 is expressed in the late stages of the cycle from ≈30 hrs all the way until the dividing merozoites. Three surf genes (surf1.3, surf4.2 and surf8.3) are expressed throughout the life cycle while others are expressed at a particular stage in the life cycle.
  2. + = Gene amplified.
  3. - = Gene not amplified.
  4. §SURFIN grouping is based on the number of exons [20] as well as protein alignments which have resulted in surf4.1 to be in group A even though it has 3 exons. The transmembrane domain in the group A paralogs is present in the first exon and in the second exon in group B paralogs
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Malaria Journal

ISSN: 1475-2875

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