Table 3 Treatment effect on four transmission outcomes:

Variable

N patients

Univariate AUC

Ratio

of arithmetic

means (95% CI)

P value

N patients

Univariate OR slide-

positive gametocytaemia on

day of feeding

(95% CI)

P value

Antimalarial

CQ (non-artemisinin)

240

1

<0.00

337

1

<0.00

SP (non-artemisinin)

325

1.56 (1.27–1.93)

1

520

3.11 (2.19–4.40)

1

CQ-SP (non-artemisinin)

198

1.03 (0.81–1.32)

227

1.33 (0.86–2.06)

CQ-AS (ACT)

291

0.72 (0.57–0.91)

344

0.42 (0.28–0.62)

SP-AS3 (ACT)

187

0.62 (0.47–0.83)

581

0.50 (0.32–0.78)

AL (Coartem) (ACT)

407

0.18 (0.13–0.25)

404

0.15 (0.08–0.29)

ACT

non-artemisinin

872

1

<0.00

1201

1

<0.00

ACT

885

0.35 (0.31–0.41)

1

1329

0.20 (0.16–0.26)

1

ACT by pre-treatment gametocytaemia

day 0 slide-negative

†

†

non-artemisinin

727

1

<0.00

994

1

<0.00

ACT

745

0.23 (0.19–0.28)

1

1125

0.13 (0.10–0.17)

1

day 0 slide-positive

non-artemisinin

145

1

0.054

164

1

ACT

140

0.80 (0.64–1.00)

183

0.41 (0.25–0.67)

<0.00

ACT by parasitological treatment failure

No failure

†

non-artemisinin

459

1

<0.00

468

1

<0.00

ACT

605

0.31 (0.25–0.37)

615

0.28 (0.20–0.38)

1

Failure

1

non-artemisinin

269

1

<0.00

303

<0.00

ACT

218

0.51 (0.40–0.65)

1

233

0.33 (0.22–0.49)

1

Mosquito-level outcomes

Variable

N mosquito es

Adjusted OR mosquito infection (95% CI)*

P value

N mosquito es

Adjusted OR oocyst count per midgut in highest 50% of positive counts (4) (95% CI)*

P value

Antimalarial

CQ (non-artemisinin)

2194

1

0.002

2194

1

<0.00

SP (non-artemisinin)

6762

0.42 (0.20–0.87)

4079

0.25 (0.09–0.75)

1

CQ-SP (non-artemisinin)

1277

1.28 (0.43–3.85)

1146

0.12 (0.03–0.58)

CQ-AS (ACT)

974

0.28 (0.11–0.71)

974

0.25 (0.05–1.21)

SP-AS3 (ACT)

2793

0.29 (0.12–0.69)

1439

0.39 (0.09–1.8)

AL (Coartem) (ACT)

2299

0.22 (0.08–0.61)

292

- ‡

ACT

non-artemisinin

11653

1

0.029

7419

1

0.165

ACT

6066

0.49 (0.33–0.73)

2705

0.45 (0.14–1.39)

ACT by pre-treatment gametocytaemia

day 0 slide-negative

non-artemisinin

8811

1

0.002

5700

1

0.008

ACT

4039

0.49 (0.31–0.77)

1419

0.11 (0.02–0.56)

day 0 slide-positive

non-artemisinin

2277

1

<0.00

1326

1

0.102

ACT

1870

0.30 (0.16–0.55)

1

1129

0.28 (0.06–1.29)

ACT by parasitological treatment failure

No failure

non-artemisinin

4773

1

0.003

2037

1

0.486

ACT

3496

0.46 (0.28–0.76)

740

0.49 (0.07–3.62)

Failure

non-artemisinin

3027

1

0.021

1574

1

0.294

ACT

897

0.37 (0.16–0.86)

572

0.33 (0.04–2.59)