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Table 2 Correlation of TNF levels with genotypes of the -1031 and -863 SNPs in controls and patients. Comparison of means was carried out by Kruskal-Wallis test.

From: Polymorphisms of TNF-enhancer and gene for FcγRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population

 

TNF levels as mean ± S.D. (pg/ml)

 

Controls (n = 100)

Patients (n = 111)

-1031

    

   TT

18.2 ± 22.17 (n = 58)

P = 0.0178

27.9 ± 29.14 (n = 58)

P = 0.0089

   TC

21.3 ± 23.2 (n = 36)

 

40.9 ± 64.9 (n = 47)

 

   CC

56.56 ± 35.1 (n = 6)a

 

126.6 ± 80.82 (n = 6)b

 

-863

    

   CC

19.01 ± 22.9 (n = 61)

P = 0.0481

25.6 ± 29.3 (n = 62)

P = 0.0231

   CA

17.79 ± 17.9 (n = 30)

 

47.5 ± 66.8 (n = 44)

 

   AA

52.27 ± 35.1 (n = 9)c

 

124.7 ± 90.2 (n = 5)d

 
  1. 'n' indicates number of individuals in each category.
  2. a,b TNF levels in TT vs. CC in controls and patients: P < 0.01 (Mann-Whitney test)
  3. c,d TNF levels in CC vs. AA in controls and patients: P < 0.02 (Mann-Whitney test)
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Malaria Journal

ISSN: 1475-2875

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