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Table 4 Sensitivity analyses on the estimated relative increase in Plasmodium falciparum parasite biomass due to HIV-1, sub Saharan Africa*

From: The impact of HIV-1 on the malaria parasite biomass in adults in sub-Saharan Africa contributes to the emergence of antimalarial drug resistance

    Relative increase parasite biomass
Best estimate (95% CI)*    18.0%(11.6–26.9)
Parameters Lower-bound assumption Upper-bound assumption Lower-bound assumption Upper-bound assumption
HIV prevalence (UNAIDS country point estimate) lower-bound higher-bound 11.4% 23.8%
Relative risk of incidence of uncomplicated symptomatic malaria, in HIV-infected individuals with CD4<200/μl and CD4 200–499 compared to HIV-negatives 4/2 6/4 15.8% 19.4%
Relative parasite density during uncomplicated symptomatic malaria, in HIV-infected patients with CD4<200/μl and CD4 200–499/μL compared to HIV-uninfected patients 2/1 4/2 15.5% 19.9%
Relative risk of progression to severe malaria, in HIV-infected individuals with CD4<200/μl and CD4 200–499/μL compared to HIV-uninfected patients 8/3 24/12 17.2% 18.6%
Relative parasite density during severe malaria, in HIV-infected patients with CD4<500/μl compared to HIV-uninfected patients 0.5/0.5 2.0/2.0 16.9% 18.2%
Assume no HIV-1 impact on incidence of symptomatic malaria, severe malaria or parasite density in children under 15 years 17.6% n.a.
Mean parasite density during uncomplicated symptomatic malaria in HIV-negative patients equal for all age groups and endemicities: 20000/μL n.a. 17.2%
  1. * For default values underlying this best estimate, see Table 2.