Table 4 Sensitivity analyses on the estimated relative increase in Plasmodium falciparum parasite biomass due to HIV-1, sub Saharan Africa*
| Â | Â | Â | Relative increase parasite biomass | |
|---|---|---|---|---|
Best estimate (95% CI)* |  |  | 18.0%(11.6–26.9) | |
Parameters | Lower-bound assumption | Upper-bound assumption | Lower-bound assumption | Upper-bound assumption |
HIV prevalence (UNAIDS country point estimate) | lower-bound | higher-bound | 11.4% | 23.8% |
Relative risk of incidence of uncomplicated symptomatic malaria, in HIV-infected individuals with CD4<200/μl and CD4 200–499 compared to HIV-negatives | 4/2 | 6/4 | 15.8% | 19.4% |
Relative parasite density during uncomplicated symptomatic malaria, in HIV-infected patients with CD4<200/μl and CD4 200–499/μL compared to HIV-uninfected patients | 2/1 | 4/2 | 15.5% | 19.9% |
Relative risk of progression to severe malaria, in HIV-infected individuals with CD4<200/μl and CD4 200–499/μL compared to HIV-uninfected patients | 8/3 | 24/12 | 17.2% | 18.6% |
Relative parasite density during severe malaria, in HIV-infected patients with CD4<500/μl compared to HIV-uninfected patients | 0.5/0.5 | 2.0/2.0 | 16.9% | 18.2% |
Assume no HIV-1 impact on incidence of symptomatic malaria, severe malaria or parasite density in children under 15 years | 17.6% | n.a. | ||
Mean parasite density during uncomplicated symptomatic malaria in HIV-negative patients equal for all age groups and endemicities: 20000/μL | n.a. | 17.2% | ||