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Table 3 Association of IgG2 and IgG4 with malaria incidence.

From: Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children

Antigen Antibody Crude IRR (95%CI) P-value Age-adjusted IRR P-value
MSP3       
  IgG2* (coded as log(2)) 0.74 (0.57, 0.98) 0.04 0.85 (0.63, 1.15) 0.29
  IgG4 < detection limit 1 0.01 1 0.20
   < median 0.45 (0.21, 0.95)   0.56 (0.26, 1.19)  
   ≥ median 0.47 (0.28, 0.79)   0.68 (0.40, 1.15)  
MSP1 19       
  IgG2* (coded as log(2)) 0.62 (0.45, 0.86) < 0.01 0.836 (0.606, 1.157) 0.275
  IgG4* (coded as log(2)) 1.07 (0.95, 1.21) 0.25 0.838 (0.608, 1.159) 0.278
GLURP       
  IgG2* (coded as log(2)) 0.65 (0.49, 0.86) < 0.01 0.79 (0.58, 1.08) 0.13
  IgG4* (coded as log(2)) 0.94 (0.81, 1.08) 0.37 1.01 (0.87, 1.16) 0.94
AMA1       
  IgG2 < detection limit 1 0.18 1 0.54
   < median 1.80 (0.86, 3.78)    
   ≥ median 1.78 (0.90, 3.51)    
  IgG4 < detection limit 1 0.19 1 0.54
   < median 0.96 (0.47, 1.93)    
   ≥ median 0.62 (0.36, 1.07)    
  1. For IgG 2 to AMA1 and for IgG4 to AMA1 and MSP3, antibody level was categorized.
  2. *For IgG2 to MSP3, MSP119 and GLURP, the association is expressed as the incidence rate ratio (IRR) corresponding to a doubling of baseline antibody level.