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Table 3 Association of IgG2 and IgG4 with malaria incidence.

From: Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children

Antigen

Antibody

Crude IRR (95%CI)

P-value

Age-adjusted IRR

P-value

MSP3

      
 

IgG2*

(coded as log(2))

0.74 (0.57, 0.98)

0.04

0.85 (0.63, 1.15)

0.29

 

IgG4

< detection limit

1

0.01

1

0.20

  

< median

0.45 (0.21, 0.95)

 

0.56 (0.26, 1.19)

 
  

≥ median

0.47 (0.28, 0.79)

 

0.68 (0.40, 1.15)

 

MSP1 19

      
 

IgG2*

(coded as log(2))

0.62 (0.45, 0.86)

< 0.01

0.836 (0.606, 1.157)

0.275

 

IgG4*

(coded as log(2))

1.07 (0.95, 1.21)

0.25

0.838 (0.608, 1.159)

0.278

GLURP

      
 

IgG2*

(coded as log(2))

0.65 (0.49, 0.86)

< 0.01

0.79 (0.58, 1.08)

0.13

 

IgG4*

(coded as log(2))

0.94 (0.81, 1.08)

0.37

1.01 (0.87, 1.16)

0.94

AMA1

      
 

IgG2

< detection limit

1

0.18

1

0.54

  

< median

1.80 (0.86, 3.78)

   
  

≥ median

1.78 (0.90, 3.51)

   
 

IgG4

< detection limit

1

0.19

1

0.54

  

< median

0.96 (0.47, 1.93)

   
  

≥ median

0.62 (0.36, 1.07)

   
  1. For IgG 2 to AMA1 and for IgG4 to AMA1 and MSP3, antibody level was categorized.
  2. *For IgG2 to MSP3, MSP119 and GLURP, the association is expressed as the incidence rate ratio (IRR) corresponding to a doubling of baseline antibody level.