Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children

Table 4 Association of IgG1 and IgG3 with malaria incidence

IgG1:	Crude IRR (95%CI)	P-value	IRR adjusted for age (95%CI)	P-value
MSP3	0.82 (0.72, 0.94)	< 0.01	0.88 (0.76, 1.03)	0.11
MSP1₁₉	0.86 (0.77, 0.97)	0.01	0.89 (0.80, 0.99)	0.04
GLURP	0.85 (0.74, 0.98)	0.02	0.93 (0.81, 1.08)	0.35
AMA1	0.95 (0.86, 1.06)	0.36	1.01 (0.90, 1.14)	0.83
IgG3:
MSP3	0.90 (0.82, 0.98)	0.01	0.94 (0.86, 1.03)	0.17
MSP1₁₉	0.90 (0.82, 0.99)	0.03	0.93 (0.84, 1.03)	0.18
GLURP	0.83 (0.74, 0.93)	< 0.01	0.91 (0.80,1.03)	0.14
AMA1	0.97 (0.89, 1.06)	0.48	0.98 (0.90, 1.07)	0.73

The incidence rate ratio (IRR) corresponds to a doubling of baseline antibody level, before and after adjustment for effects of age

ISSN: 1475-2875