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Table 4 Day 28 failure rates estimated by four methods – AS+SP treatment

From: Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children

   Day 28 failure rates
Year Country &
Site
Method 1a
(per protocol)
Method 1b Method 2a
(WHO 2001)
Method 2b
2002 Zambia, Maheba 21.7 13.2 15.4 29.8
   [10.9–36.4] [6.5–22.9] [8.6–26.8] [20.5–42.1]
2003 Angola, Kuito 1.2 1.2 1.1 2.3
   [0–6.6] [0–6.4] [0.2–7.8] [0.6–8.8]
2003 DRC, Boende 33.3 25.3 27.3 59.5
   [21.9–46.3] [16.4–36.0] [18.7–38.9] [48.8–70.5]
2003 S Sudan, Nuba 10.3 8.3 8.6 10.5
   [3.9–21.2] [3.1–17.3] [4.0–18.2] [5.4–19.9]
2003 Uganda, Amudat 7.9 6.8 6.8 8.0
   [2.6–17.5] [2.2–15.1] [2.9–15.5] [3.7–16.9]
2004 Congo, Kindamba 11.1 10.0 10.1 11.0
   [4.9–20.7] [4.4–18.8] [5.2–19.2] [5.9–20.2]
2004 DRC, Kabalo 2.3 2.0 2.0 11.8
   [0–12.3] [0–10.8] [0.3–13.4] [5.5–24.4]
2004 Guinea, Dabola 1.0 0.9 0.9 2.8
   [0–5.5] [0–5.2] [0.1–6.5] [0.9–8.5]