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Table 2 Laboratory markers of malaria disease severity

From: Reduced paediatric hospitalizations for malaria and febrile illness patterns following implementation of community-based malaria control programme in rural Rwanda

  n (%)   
Pre Post PR* [95% CI] chi-squared
p-value
Slide-positive (N = 386) 205 (80.4) 63 (48.1) 1.67 [1.39–2.02] <0.0001
Suspected malaria, no slide results available (N = 51) 32 (11.1) 19 (12.7) 0.88 [0.52–1.50] 0.64
High parasitaemia (N = 268) 116 (56.6) 22 (34.9) 1.62** [1.11–2.38] 0.004
Severe anemia, slide-positive admissions (N = 161) 21 (18.9) 4 (8.0) 2.47** [0.84–7.24] 0.08
Severe anemia, all hospitalizations (N = 307) 23 (15.3) 6 (3.8) 3.85** [1.60–9.25] 0.001
No hemoglobin result (N = 244) 172 (53.4) 72 (31.4) 1.70 [1.37–2.11] <0.0001
  1. Results for laboratory-definable markers of disease severity: admission haemoglobin and admission peripheral parasitaemia are shown. For parasitaemia, percents are recorded as proportion of pre-intervention, post-intervention, or total admissions for malaria for which a slide result was available. For low vs. high (3+-4+) parasitaemia, percents are recorded as proportion of total slide-positive malaria admissions. For missing data, percentages are recorded as proportion of total malaria admissions for which slide results were unavailable. Severe anemia is defined as ≤ 5 g/dl. * Prevalence ratio comparing the proportion in the pre-intervention period to the proportion in the post-intervention period. ** adjusted for age using three categories (<1 year; 1–5 years; > 5 years)