Table 6 Risk factors for a male-biased gametocyte sex ratio 7 days after amodiaquine treatment of children with uncomplicated falciparum malaria, showing the crude and adjusted odd ratios (OR) and their 95% confidence intervals (CI)
Variables | Total Number | No with gsr ≥ 0.5 | OR (95% CI) | P value | AOR (95% CI) | P value |
|---|---|---|---|---|---|---|
Gender | ||||||
male | 25 | 7 | 1 | |||
female | 25 | 8 | 1.1 (0.6 – 2) | 0.75 | - | - |
Age | ||||||
< 5 years | 20 | 7 | 1 | |||
≥ 5 years | 30 | 8 | 0.8 (0.5 – 1.4) | 0.5 | - | - |
Duration of illness | ||||||
≤ 3 days | 38 | 12 | 1 | |||
> 3 days | 12 | 3 | 0.8 (0.2 – 2.5) | 0.67 | - | - |
Fever* | ||||||
afebrile | 21 | 6 | 1 | |||
febrile | 29 | 9 | 1.1 (0.6 – 1.7) | 0.85 | - | - |
PCV (day 0) | ||||||
< 25% | 6 | 5 | 1 | 1 | ||
≥ 25% | 44 | 10 | 0.6 (0.5 – 1) | 0.002 | 0.06 (0.006 – 0.7) | 0.03 |
Parasitaemia (day 0) | ||||||
≤ 20,000 μl/l | 22 | 3 | 1 | 1 | ||
> 20,000 μl/l | 28 | 12 | 1.8 (1.1 – 2.7) | 0.025 | 5.7 (1 – 33) | 0.05 |
Gametocytaemia (day 0) | ||||||
< 18 μl/l | 11 | 4 | 1 | |||
≥ 18 μl/l | 17 | 7 | 1.1 (0.6 – 2) | 0.8 | - | - |
Year | ||||||
pre 2006 | 34 | 8 | 1 | |||
2006 | 16 | 7 | 1.8 (0.8 – 4) | 0.15 | - | - |
GSR (day 0) | ||||||
< 0.5 | 26 | 10 | 1 | |||
≥ 0.5 | 2 | 1 | 1.5 (0.1 – 22) | 0.75 | - | - |
FCT | ||||||
< 2 days | 33 | 10 | 1 | |||
≥ 2 days | 2 | 1 | 2.2 (0.1 – 32) | 0.56 | - | - |
PCT | ||||||
< 3 days | 32 | 8 | 1 | |||
≥ 3 days | 18 | 7 | 1.5 (0.7 – 3.1) | 0.3 | - | - |
PCV (day 7) | ||||||
< 25% | 4 | 3 | 1 | 1 | ||
≥ 25% | 46 | 12 | 0.8 (0.6 – 3.7) | 0.04 | 0.06 (0.003 – 1) | 0.05 |
Re-parasitaemia | ||||||
Absent | 44 | 14 | 1 | |||
Present | 6 | 1 | 0.5 (0.06 – 3.7) | 0.45 | - | - |