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Table 2 Infection prevalence and MOI in subjects stratified by blood groups and haemoglobinopathies before and after the transmission season

From: Multiplicity of Plasmodium falciparum infection in asymptomatic children in Senegal: relation to transmission, age and erythrocyte variants

  

June 2002

January 2003

 

Whole groupa n (%)

nb (%)

MOI; mean (range)

nb (%)

MOI; mean (range)

Blood group

     

   O

193 (52)

81/193 (42)

2.6 (1 – 7)

99/193 (51)

4.1 (1–10)g***

   A

100 (27)

47/100 (47)

2.6 (1 – 7)

50/100 (50)

4.0 (1 – 9)g**

   B

69 (18)

34/69 (49)

2.3 (1 – 6)

32/69 (46)

4.2 (1 – 10)g*

   AB

10 (3)

2/10 (20)

4.0 (1 – 7)

7/10 (70)

4.6 (2 – 8)g*

Hemoglobin

     

   AA

319 (86)

144/319 (45)

2.5 (1 – 7)

162/319 (51)

4.0 (1–10)g***

   AS

51 (14)

19/51 (37)

2.7 (1 – 5)

26/51 (51)

4.5 (1 – 10)g**

α+-thalassemiaC

     

   Normal

234 (76)

103/234 (44)

2.3 (1 – 7)

118/234 (50)

3.9 (1–10)g***

   Mutation

75 (24)

37/75 (49)

2.8 (1 – 7)

36/75 (48)

4.1 (1 – 9)

G6PD in femalesd

     

   Normal

141 (81)

60/141 (43)

2.7 (1 – 7)

73/141 (52)f

4.4 (1 – 10)g**

   Mutation

34 (19)

11/34 (32)

2.7 (1 – 4)

9/34 (26)

4.6 (1 – 10)

G6PD in malese

     

   Normal

166 (87)

77/166 (46)

2.5 (1 – 7)

90/166 (54)

3.8 (1–10)g***

   Mutation

24 (13)

14/24 (58)

1.7 (1 – 4)

14/24 (58)

3.4 (1 – 7)

  1. a Total number of samples = 372, missing values for hemoglobin (n = 2), α+-thalassemia (n = 63) and G6PD (n = 7).
  2. b Proportion of infected individuals to total.
  3. c Mutation indicated in both heterozygous and homozygous state.
  4. d G6PD mutations include G6PD A-/B, A-/A heterozygous and A-/A- homozygous genotypes.
  5. e G6PD mutation corresponds to A- hemizygous genotype.
  6. f Significantly less infection prevalence in G6PD mutated girls as compared to normal ones; χ2-test, P < 0.01.
  7. g Wilcoxon signed rank test for the comparison of MOI in June and January;
  8. * P < 0.05
  9. ** P < 0.01
  10. *** P < 0.0001