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Table 1 αMSP1-19kD by age group. In Plasmodium-negativea individuals, αMSP1-19kD IgG responsesb differed by age groupc, but were similar within age group at the beginning versus end of the malaria seasond.

From: Antibody response dynamics to the Plasmodium falciparum conserved vaccine candidate antigen, merozoite surface protein-1 C-terminal 19kD (MSP1-19kD), in Peruvians exposed to hypoendemic malaria transmission

Malaria status Age group Anti-MSP-1 19KD IgG response stratification Mar., 2003 (%, n) Feb., 2004 (%, n) Aug., 2004 (%, n)
NEG Adults ≤ negative cut-off 16.2% 33 38.2% 68 35.4% 40
NEG Adults > negative cut-off, but < 3 times negative cut-off 20.6% 17 13.5% 24 21.2% 24
NEG Adults ≥ 3 times negative cut-off 63.2% 92 48.3% 86 43.4% 49
NEG Children ≤ negative cut-off 54.2% 107 71.1% 118 73.3% 77
NEG Children > negative cut-off, < 3 times negative cut-off 23.2% 17 10.8% 18 10.5% 11
NEG Children ≥ 3 times negative cut-off 22.6% 40 18.1% 30 16.2% 17
   p (chisq): age group by IgG response < 0.0001 < 0.0001 < 0.0001
  1. aMalaria negative (NEG) = no Plasmodium infection (neither P. falciparum nor P. vivax) detected by microscopy or PCR.
  2. bAntibody response stratification: Negative ≤ negative cut-off; High-Positive ≥ 3 times negative cut-off; Low-Positive > Negative and < High-Positive.
  3. cAdults = ≥ 14 years old.
  4. dFebruary 2004 = beginning of transmission season. August 2004 = end of transmission season.