Antibody response dynamics to the Plasmodium falciparum conserved vaccine candidate antigen, merozoite surface protein-1 C-terminal 19kD (MSP1-19kD), in Peruvians exposed to hypoendemic malaria transmission

Table 2 Comparison of αMSP1-19kD IgG responses with malaria infection status during community surveys.

Malaria status	Age group	N (n < neg cut-off, n > 3* neg cut-off)	Median	Lower quartile	Upper quartile	p (WRS test)
PF	Adults	14 (1, 14)	1.446	1.141	1.851	0.3132
PF	Children	14 (3, 8)	1.339	0.740	1.803
NEG	Adults	433 (141, 227)	1.040	0.505	1.562	<0.0001
NEG	Children	435 (302, 89)	0.301	0.161	0.827

In adults, P. falciparum infected, P. vivax infected, and Plasmodium-negative (NEG) individuals had similar αMSP1-19kD IgG OD levels. The low αMSP1-19kD response frequency in NEG children suggests that fewer children had prior P. falciparum infection which could explain the maintained αMSP1-19kD antibody response seen in adults.

ISSN: 1475-2875