Antibody response dynamics to the Plasmodium falciparum conserved vaccine candidate antigen, merozoite surface protein-1 C-terminal 19kD (MSP1-19kD), in Peruvians exposed to hypoendemic malaria transmission

Table 3 Adult and child IgG response profile as compared with clinical data during longitudinal follow-up.

IgG response profile category		# with clinical information complete	% in each response category	# with febrile illness	% with febrile illness	GMP (95% CI)
Adult	Pre-Positive	22	48.9%	4	18.2%	19	(6–60)
	Infection-Positive	18	40.0%	9	50.0%	78	(37–164)
	Late-Positive	1	2.2%	0	0	16	n/a
	Non-responder	4	8.9%	3	75.0%	156	(12–2027)
Child	Pre-Positive	6	18.2%	1	16.7%	8	(1–53)
	Infection-Positive	16	48.5%	12	75.0%	284	(121–669)
	Late-Positive	4	12.1%	4	100.0%	1210	(754–1941)
	Non-responder	7	21.2%	6	85.7%	120	(26–561)

Adult and child IgG response profile was compared with febrile illness (patient-reported history or measured by physician within one week of infection) and parasite density, where infections were detected during one of 4 weekly active sampling visits. A pre-positive response, most frequently observed in adults, was associated with less febrile illness (χ², p = 0.0056) and lower parasite density (WRS, p = 0.0005).

ISSN: 1475-2875