Skip to main content

Advertisement

Table 3 Adult and child IgG response profile as compared with clinical data during longitudinal follow-up.

From: Antibody response dynamics to the Plasmodium falciparum conserved vaccine candidate antigen, merozoite surface protein-1 C-terminal 19kD (MSP1-19kD), in Peruvians exposed to hypoendemic malaria transmission

IgG response profile category # with clinical information complete % in each response category # with febrile illness % with febrile illness GMP (95% CI)
Adult Pre-Positive 22 48.9% 4 18.2% 19 (6–60)
  Infection-Positive 18 40.0% 9 50.0% 78 (37–164)
  Late-Positive 1 2.2% 0 0 16 n/a
  Non-responder 4 8.9% 3 75.0% 156 (12–2027)
Child Pre-Positive 6 18.2% 1 16.7% 8 (1–53)
  Infection-Positive 16 48.5% 12 75.0% 284 (121–669)
  Late-Positive 4 12.1% 4 100.0% 1210 (754–1941)
  Non-responder 7 21.2% 6 85.7% 120 (26–561)
  1. Adult and child IgG response profile was compared with febrile illness (patient-reported history or measured by physician within one week of infection) and parasite density, where infections were detected during one of 4 weekly active sampling visits. A pre-positive response, most frequently observed in adults, was associated with less febrile illness (χ2, p = 0.0056) and lower parasite density (WRS, p = 0.0005).