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Table 3 Symptoms and clinical signs

From: Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial

Drug Group Quinine Atovaquone-proguanil Artemether-lumefantrine
n = 30 30 30 23 30 30 30 26 30 30 30 28
day 0 7 28 90 0 7 28 90 0 7 28 90
Hearing Problem 0 9 1 0 0 1 0 1 1 2 1 0
Tinnitus 2 8 3 0 4 6 1 1 6 4 2 0
Vertigo 6 0 1 0 8 1 0 0 4 3 1 0
Imbalance 1 0 0 0 0 0 0 0 0 0 0 0
Spontaneous nystagmus 0 0 0 0 0 0 0 0 0 0 0 0
Provoked nystagmus 0 0 0 0 0 0 0 0 0 0 0 0
Pathologic head rotation test 1 0 0 0 0 0 0 0 1 0 0 0
Impaired coordination 0 0 0 0 0 0 0 0 0 0 0 0
Fever 24 0 5 2 23 2 3 1 26 0 1 2
Shivering 23 0 1 2 26 4 3 1 21 1 1 1
Headache 30 5 5 2 30 10 6 3 30 7 4 2
Nausea 21 1 2 0 17 1 1 0 22 0 0 4
Diarrhea 4 0 0 0 2 1 1 0 3 0 0 0
Vomiting 1 0 0 0 1 0 0 0 1 0 0 0
Anorexia 2 0 1 0 3 0 0 0 0 0 0 0
Abdominal pain 1 0 0 0 0 0 0 0 1 0 0 0
Arthralgia 3 0 0 0 3 0 0 0 1 0 0 0
Myalgia 1 0 0 0 0 0 0 0 0 0 0 0
Chest pain 0 0 0 0 0 1 0 0 0 0 0 0
Cough 0 1 0 0 0 1 0 0 0 0 0 0