Table 3 Symptoms and clinical signs
From: Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial
Drug Group | Quinine | Atovaquone-proguanil | Artemether-lumefantrine | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
n = | 30 | 30 | 30 | 23 | 30 | 30 | 30 | 26 | 30 | 30 | 30 | 28 |
day | 0 | 7 | 28 | 90 | 0 | 7 | 28 | 90 | 0 | 7 | 28 | 90 |
Hearing Problem | 0 | 9 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 2 | 1 | 0 |
Tinnitus | 2 | 8 | 3 | 0 | 4 | 6 | 1 | 1 | 6 | 4 | 2 | 0 |
Vertigo | 6 | 0 | 1 | 0 | 8 | 1 | 0 | 0 | 4 | 3 | 1 | 0 |
Imbalance | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spontaneous nystagmus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Provoked nystagmus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pathologic head rotation test | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Impaired coordination | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fever | 24 | 0 | 5 | 2 | 23 | 2 | 3 | 1 | 26 | 0 | 1 | 2 |
Shivering | 23 | 0 | 1 | 2 | 26 | 4 | 3 | 1 | 21 | 1 | 1 | 1 |
Headache | 30 | 5 | 5 | 2 | 30 | 10 | 6 | 3 | 30 | 7 | 4 | 2 |
Nausea | 21 | 1 | 2 | 0 | 17 | 1 | 1 | 0 | 22 | 0 | 0 | 4 |
Diarrhea | 4 | 0 | 0 | 0 | 2 | 1 | 1 | 0 | 3 | 0 | 0 | 0 |
Vomiting | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Anorexia | 2 | 0 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Abdominal pain | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Arthralgia | 3 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Myalgia | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chest pain | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cough | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |