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Table 2 Results of the levels of different antibodies isotypes and their avidity against P. falciparum blood stages determined by ELISA in serum from 233 individuals infected with Plasmodium and classified according to the different clinical expressions of malaria: complicated malaria (CM), uncomplicated malaria (UM) and asymptomatic malaria (AS).

From: Pattern of humoral immune response to Plasmodium falciparum blood stages in individuals presenting different clinical expressions of malaria

  Levels of antibodies against P. falciparum blood stages Statistical
  CM UM AS P
IgG1* 2.28 (0.80–10.37) 18.40 (7.23–44.8) 38.4 (3.95–71.8) < 0.0001
AI-IgG1+ 35.1 (24.7–64.7) 66.4 (44.4–86.7) 71.9 (62.2–84.6) < 0.0001
IgG2* 1.33 (0.67–3.00) 3.92 (2.26–17.1) 9.81 (2.25–89.8) < 0.0001
AI-IgG2+ 20.4 (16.8–68.6) 58.0 (37.5–76.6) 75.3 (62.0–92.6) 0.014
IgG3* 0.43 (0.19–0.91) 1.53 (0.72–3.74) 2.41 (0.53–9.47) < 0.0001
AI-IgG3+ 43.5 (22.0–53.6) 42.9 (27.1–66.5) 37.1 (29.4–53.3) 0.813
IgG4* 0.06 (0.00–0.14) 0.01 (0.00–0.04) 0.01 (0.00–0.03) 0.002
AI-IgG4+ 40.0 (2.8–77.8) 48.9 (36.0–59.1) - 0.471
IgG# 2.47 (0.73–5.44) 2.92 (1.36–4.39) 4.71 (1.59–6.58) 0.190
AI-IgG+ 48.4 (34.7–69.7) 63.3 (46.8–73.2) 63.4 (58.2–69.8) 0.036
IgE* 0.07 (0.03–0.16) 0.03 (0.00–0.11) 0.03 (0.01–0.21) 0.07
IgM# 1.08 (0.65–2.08) 0.86 (0.59–1.50) 1.04 (0.58–2.00) 0.106
IgA# 0.93 (0.56–2.09) 0.87 (0.60–1.88) - 0.661
  1. *Levels expressed as concentration median (μg/mL)
  2. # Levels expressed as the index of reactivity (IR) calculated as [sample optical density (OD)/cut-off OD]
  3. + AI = avidity index mean, calculated as (urea-treated sample OD/PBS sample OD)*100
  4. P value for Kruskal Wallis non-parametric test