IC50 (nmol/L)a | |||
---|---|---|---|
Test compounds | 3D7 | D10 | Dd2 |
1. Peptide proteasome inhibitors | |||
Epoxomicin | 6.8 | 1.7 | 10.4 |
YU101 | 24.5 | 17.0 | 13.8 |
YU102 | 1740 | 4000 | 3006 |
MG115 | 97.5 | 50.0 | 44.9 |
MG132 | 22.4 | 33.2 | 17.3 |
Z-L3-VS | 16.4 | n.d. | 4.9 |
Ada-Ahx3-L3-VS | 300 | n.d. | 210 |
Bortezomib | 252 | 127 | 561 |
2. β-lactone | |||
Lactacystin | 1490 | 1211 | 2553 |
3. Allosteric inhibitors | |||
Gliotoxin | 2171 | n.d. | 1165 |
PR11 | n.i. | n.d. | n.i. |
PR39 | n.i. | n.d. | n.i. |
4. Comparator drugs | |||
Artesunate | 0.5 | 2.5 | 0.9 |
Chloroquine | 8.3 | 5.0 | 176 |