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Table 1 Measured and fitted values of first order rate constant k for (a) anti-MSP-119 and (b) anti-MSP-2 recoveries from spots on 3 MM paper

From: Dried blood spots as a source of anti-malarial antibodies for epidemiological studies

(a) MSP119

     

Temp (°C)

Measured k (days-1)

Fitted k (days-1)

(95% CI)

t1/2

(95% CI) (years)

-20

 

0.00007

(0.00003–0.00014)

27.9

(13.1–59.4)

4

 

0.00058

(0.00037–0.00091)

3.3

(2.1–5.1)

10

 

0.00094

(0.00064–0.00138)

2.0

(1.4–2.9)

20

 

0.00202

(0.00153–0.00266)

0.94

(0.71–1.24)

23

0.0025789

0.00248

(0.00193–0.00319)

0.77

(0.59–0.99)

35

0.0053228

0.00564

(0.00477–0.00665)

0.34

(0.29–0.40)

47

0.0110235

0.01201

(0.01042–0.01385)

0.16

(0.14–0.18)

57

0.0281645

0.02258

(0.01882–0.02709)

0.08

(0.07–0.10)

65

0.0311997

0.03512

(0.02792–0.04417)

0.05

(0.04–0.07)

(b) MSP-2

     

Temp (°C)

Measured k (days-1)

Fitted k (days-1)

(95% CI)

t1/2

(95% CI) (years)

-20

 

0.00007

(0.00003–0.00014)

28.8

(13.8–60.2)

4

 

0.00059

(0.00038–0.00091)

3.2

(2.1–5.0)

10

 

0.00096

(0.00067–0.00139)

2.0

(1.4–2.8)

20

 

0.00209

(0.00159–0.00273)

0.91

(0.70–1.19)

23

0.00248

0.00260

(0.00204–0.00332)

0.73

(0.57–0.93)

35

0.00629

0.00605

(0.00516–0.00709)

0.31

(0.27–0.37)

47

0.01342

0.01319

(0.01147–0.01517)

0.14

(0.13–0.17)

57

0.03154

0.02418

(0.02020–0.02895)

0.08

(0.07–0.09)

65

0.03723

0.03828

(0.03047–0.04809)

0.05

(0.04–0.06)

  1. Measured and fitted values of k together with confidence limits are shown together with extrapolated values and confidence intervals for other selected temperatures and calculated half-lives