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Table 3 Reinfection risk of untreated children during 61 days after scheduled time of IPTi application

From: Therapeutic and prophylactic effect of intermittent preventive anti-malarial treatment in infants (IPTi) from Ghana and Gabon

Eventa

IPTi-1

IPTi-2

IPTi-3

 

n

% (CI)

n

% (CI)

n

% (CI)

Kumasi

n = 449

 

n = 428

 

n = 368

 

Parasitaemia

90

20.0 (16.4–24.1)

107

25.0 (21.0–29.4)

111

30.2 (25.5–35.1)

   Asymptomatic

66

14.6 (11.6–18.3)

62

14.5 (11.3–18.2)

61

16.6 (12.9–20.8)

   Symptomatic

24

5.4 (3.5–7.8)

45

10.5 (7.8–13.8)

50

13.6 (10.3–17.5)

Lambaréné

n = 484

 

n = 412

 

n = 317

 

Parasitaemia

3

0.6 (0.1–1.8)

12

2.9 (1.5–5.0)

3

1.0 (0.2–2.7)

   Asymptomatic

1

0.2 (0.0–1.1)

1

0.2 (0.0–1.3)b

0

0.0 (0.0–1.2)b

   Symptomatic

2

0.4 (0.1–1.5)

11

2.7 (1.3–4.7)

3

1.0 (0.2–2.7)

  1. CI, 95% confidence interval.
  2. Denominator is the number of children from the placebo group without parasitaemia at scheduled time of IPTi application and with at least one available parasite assessment during the 61 days after IPTi application. The difference between the proportion of infected individuals in Kumasi and Lambaréné was always significant with at least p < 0.0001.
  3. a Nominators are number of events during 61 days after scheduled time of IPTi application.
  4. b One-sided, 97.5% confidence interval.