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Table 1 Trial participants, interventions and outcomes

From: Artemisinin derivatives versus quinine in treating severe malaria in children: a systematic review

Reference Participants Interventions (drugs, route of administration and treatment duration) Outcomes
[8] 54 children aged 1 to 5 years in Nigeria (1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for 4 days Mortality, parasite clearance time, fever clearance time, coma resolution time, 28th day cure rate, adverse effects & neurological sequelae
   (2) IV Quinine 20 mg/kg loading dose then 10 mg 8 hrly for 7 days. This was changed to oral dose when patient was able to drink  
[9] 160 children aged 5 month to 12 years in Kenya (1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for 2 days. One dose of SP was given after parasite clearance. Mortality, parasite clearance time, fever clearance time, coma resolution time, adverse effects & neurological sequelae
   (2) IV Quinine 20 mg/kg loading dose then 10 mg 8 hrly for at least 3 days. Then one dose of SP was given after parasites clearance and when the patient was able to drink  
[10] 576 children aged 1 to 9 years in Gambia (1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for 3 days Mortality, parasite clearance time, fever clearance time, coma resolution time, 28th day cure rate, adverse effects & neurological sequelae
   (2) IM Quinine 20 mg/kg loading dose then 10 mg 8 hrly for 5 days. This was changed to oral dose when the patient was able to drink  
[11] 72 children aged 3 months to 14 years in Vietnam (1) IM Artesunate 3 mg/kg initially and 2 mg/kg at 12, 24,48 and 72 hrs, followed by oral mefloquine 15 mg/kg at 96 hours Mortality, parasite clearance time, fever clearance time, coma resolution time, duration of hospital stay, adverse effects & neurological sequelae
   (2) IM Quinine 20 mg/kg loading dose then 10 mg 8 hrly for 7 days, followed by single dose of pyrimethamine/sulfadoxine on day 7  
[12] 164 children in Malawi (age range not stated) (1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for 4 days Mortality, parasite clearance time, fever clearance time, coma resolution time, coma resolution time, 28th day cure rate, adverse effects & neurological sequelae
   (2) IV Quinine(20 mg/kg loading dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink  
[13] 37 children in Nigeria (age range not stated) (1) IM Artemether 3.2 mg/kg starting dose, then 1.6 mg/kg 12 hours later, then 1.6 mg/kg per day for 2 days Mortality, percentage of children with parasites clearance at day 7, fever clearance time, coma resolution time & neurologic sequelae
   (2) IV Quinine 10 mg/kg initial dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink  
[14] 103 children aged 1 to 5 years in Nigeria (1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for 4 days Mortality, parasite clearance time, fever clearance time, coma resolution time, 28th day cure rate & neurological sequelae
   (2) IV Quinine 20 mg/kg loading dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink  
[15] 92 children aged 0–10 years in Zambia (1) IM β-Arteether 3.2 mg/kg in the first day, then 1.6 mg/kg for next 4 days Mortality, parasite clearance time, fever clearance time, coma resolution time, adverse effects & neurological sequelae
   (2) IV Quinine (20 mg/kg loading dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink  
[16] 102 children aged 0–10 years in Cameroon (1) IM β-Arteether 3.2 mg/kg in the first day, then 1.6 mg/kg for 4 days Mortality, parasite clearance time, fever clearance time, coma resolution time, adverse effects, 28th cure rate & neurological sequelae
   (2) IV Quinine 20 mg/kg loading dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink  
[17] 41 children in Sudan (age range not stated) (1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for t 4 days Mortality, parasite clearance time, fever clearance time, coma resolution time & adverse effects
   (2) IV Quinine 20 mg/kg loading dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink  
[18] 77 children aged 3 months to 15 years in Sudan (1) IM Artemether 1.6 mg/kg, repeated after 12 hrs, then daily for 4 days Mortality, parasite clearance time, fever clearance time, coma resolution time & 28th day cure rate
   (2) IV Quinine 10 mg/kg 8 hrly for 7 days, changed to oral dose when patient was able to drink  
[19] 46 children aged 0–14 years from India (1) IM Artemether 3.2 mg/kg in the first day, then 1.6 mg/kg for 5 days Mortality, parasite clearance time, fever clearance time, coma resolution time & adverse effects
   (2) IV Quinine (20 mg/kg loading dose then 10 mg 8 hrly for 7 days, changed to oral dose when patient was able to drink