Figure 1

Interactions between P. falciparum PFE1590w and human apolipoproteins ApoA, ApoE and ApoB identified by high-throughput screens. (A) The fragments of PFE1590w involved in the interactions with human apolipoproteins are depicted above a diagram of the full-length protein, with the amino-terminal signal peptide (SP) and the transmembrane domain (TM) indicated. Low complexity regions are shown below. The human apolipoproteins that interacted with each PFE1590w peptide are listed to the right. The domain predicted by Phobius [30] to be exposed to the cytoplasm is shown. Numbers correspond to amino acid coordinates. (B) The fragments of ApoA1 and ApoE involved in the interactions were aligned by the MAVID/AMAP multiple alignment server [48]. The box indicates the region conserved among all ApoA1 and ApoE protein fragments identified in the screens.