Table 5 SNPs and amino-acids changes in aldolases and pLDHs in P. falciparum and P. vivax isolates collected in Madagascar in 2006, from different geographic areas.
Genes | SNP (bp position and change) | Amino acid change (aa position and change) | Frequency No (%) |
|---|---|---|---|
P. falciparum aldolase | 815 (CAC to CGC) | 104 (H to R) | 2 (0.8) |
1314 (CCA to CCC) | synonymous change | 1 (0.4) | |
1404 (CAC to CAG) | 300 (H to Q) | 2 (0.8) | |
1417 (ACC to GCC) | 305 (T to A) | 1 (0.4) | |
P. vivax aldolase | 510 (TCC to TCA) | synonymous change | 1 (0.9) |
651 (TTA to TTG) | synonymous change | 43 (39.1) | |
P. falciparum LDH | 73 (CAG to AAG) | 25 (Q to K) | 1 (0.7) |
814 (GAT to AAT) | 272 (D to N) | 10 (7.3) | |
P. vivax LDH | 168 (ATG to ATA) | 56 (D to N) | 1 (0.9) |
225 (AAG to AAA) | synonymous change | 84 (75.7) | |
405 (ATC to ATT) | synonymous change | 2 (1.8) | |
498 (GTC to GTT) | synonymous change | 1 (0.9) | |
544 (GTT to ATT) | 182 (V to I) | 1 (0.9) | |
627 (GTG to GTC) | synonymous change | 32 (28.8) | |
687 (GCC to GCT) | synonymous change | 23 (20.7) |