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Table 6 Multivariate analysis for gametocytaemia after enrolment up to day 14.

From: Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity

 

OR [95% CI]

P-value

 

Thailand

(N = 2633)

The Gambia

(N = 1031)1

Tanzania

(N = 592)

Log 10 parasitaemia

NS

1.503 [1.177–1.919]

0.001

No Data

History of illness

 

No Data

NS

   < 3 days

1.000

  

   > = 3 days

2.909 [2.126–3.981]

  
 

< 0.001

  

Haematocrit

0.875 [0.852–0.898]

0.965 [0.938–0.994]

No Data

 

< 0.001

0.017

 

Palpable spleen

 

No Data

NS

   No

1.000

  

   Yes

1.433 [1.050–1.955]

  
 

0.023

  

Mixed infection

0.362 [0.204–0.641]

No Data

No Data

 

0.001

  

Treatment 2

   

   A

1.000

1.000

1.000

   C-F

2.964 [2.048 4.290]

1.661 [0.709–3.893]

3.432 [1.483–7.946]

 

< 0.001

0.243

0.004

   G-H

 

12.320 [8.757–17.333]

5.520 [1.724–17.675]

  

< 0.001

0.002

Age (years)

NS

NS

 

   0–5

  

1.000

   5–15

  

0.750 [0.465–1.210]

0.238

   > 15

  

0.409 [0.250–0.671]

< 0.001

  1. Only covariates significant in at least one model are shown.
  2. 1 fixed effects model was fitted since test for random effects not significant
  3. 2 treatments groups are defined as: A: artemisisnin combination alone or with other treatments;
  4. C-F: other monotherapies (see Table 1); G-H: SP alone or SP with chloroquine. OR are calculated with reference to group A.
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Malaria Journal

ISSN: 1475-2875

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