Figure 1

Dose depandant increase in survival in recombinant human Erythropoietin-treated mice with cerebral malaria. Dose dependant increase in survival in recombinant human erythropoietin-treated mice with CM: Cumulative survival analysis of mice ECM treated with rhEpo from day 4–7 in different doses from 1–200 U daily versus vehicle treated controls. Mice treated with a high dose (50–200 U daily, red lines) show increased survival by the end of the second week of 44.4%, 42.9% and 55.6% respectively while all saline treated controls (black dotted line) survive no longer than day 11 (p < 0.001). Mice treated with 25 U daily survive in 30% (p < 0.001 vs. vehicle). Survival of mice treated with a low dose (1–10 U daily) did not show a statistically significant increase in survival. Statistical test: log rank statistic for the survival curves with pair wise comparison using the Holm-Sidak method.