Figure 2

Packed cell volume in recombinant human erythropoietin-treated and untreated mice with cerebral malaria. Packed cell volume (PCV) measured on day 8 in animals treated on day 4–7 or 1–7 respectively and vehicle treated controls: Treatment with recombinant human erythropoietin (rhEpo) increases PCV levels in mice with cerebral malaria. 1 U daily from day 4–7 increases the PCV to 51% while 10 U or more daily given on day 4–7 lead to mean PCV levels between 58.4% and 59.7%. PCV levels in the group treated on day 1–7 with 100 U daily reached very high values of 73.0% unless these mice where bled for 10% of their total blood volume on day 5. This intervention reduced the mean PCV level to 58.6% (right plot). P < 0.001. Statistical test: One way ANOVA. The ends of the boxes define the 25th and 75th percentiles, with a line at the median and error bars defining the 10th and 90th percentiles.