Figure 6

Gene expression in the brains of recombinant human erythropoietin-treated and untreated mice with cerebral malaria. Gene expression in the brains of recombinant human erythropoietin-treated and untreated mice with cerebral malaria on day 8 relative to uninfected control mice (black columns). Increased gene expression in infected mice was seen for IL-1β, TNF, INF-γ (P < 0.001) and Caspase 1 (P < 0.05), but not for LT-α, and Caspase 3. Gene expression for the IL-β, TNF and INF-γ was significantly reduced in rhEpo treated mice (P < 0.001). The treatment does not alter the expression of LT-α and the Caspases 1 and 3. Statistical test: Two way ANOVA. Values are presented as mean values relative to uninfected controls. Error bars: Standard deviation (** = P < 0.001).