Table 2 Frequency distribution of mutant-type alleles for DHFR and DHPS domains in 159 Malagasy isolates collected from 7 sites in 2006–2007
P. vivax dhfr polymorphism | P. vivax dhps polymorphism | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sampling site | No. of isolates | No. of mutant isolates (%) | Amino-acid residue | No. of mutant isolates (%) | Amino-acid residue | |||||||
P21S | P33L | C49R | S58R | S117N | N130K | A383G | C422R | |||||
South | Ejeda | 11 | 2 (18) | - | 1 | - | 1 | 1 | - | 0 (0) | 0 | 0 |
Ihosy | 1 | 1 (100) | - | - | - | - | 1 | - | 0 (0) | 0 | 0 | |
West | Miandrivazo | 60 | 50 (83) | 1 | 1 | - | 43 | 47 | 44 | 2 (3) | 1 | 1 |
Maevatanana | 22 | 14 (64) | - | 2 | 5 | 12 | 12 | - | 8 (36) | 8 | 0 | |
Central Highlands | Tdd | 59 | 42 (71) | 1 | 4 | - | 33 | 37 | 6 | 11 (19) | 11 | 0 |
Moramanga | 5 | 3 (60) | - | 1 | - | 2 | 2 | - | 3 (60) | 3 | 0 | |
East | Farafangana | 1 | 1 (100) | - | - | - | 1 | 1 | - | 1 (100) | 1 | 0 |
Total | 159 | 113 (71) | 2 (1.3) | 9 (5.7) | 5 (3.1) | 92 (57.9) | 101 (63.5) | 50 (31.4) | 25 (16) | 24 (15) | 1 (0.6) | |