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Table 2 Frequency distribution of mutant-type alleles for DHFR and DHPS domains in 159 Malagasy isolates collected from 7 sites in 2006–2007

From: Plasmodium vivax dhfr and dhps mutations in isolates from Madagascar and therapeutic response to sulphadoxine-pyrimethamine

    P. vivax dhfr polymorphism P. vivax dhps polymorphism
Sampling site No. of isolates No. of mutant isolates (%) Amino-acid residue No. of mutant isolates (%) Amino-acid residue
     P21S P33L C49R S58R S117N N130K   A383G C422R
South Ejeda 11 2 (18) - 1 - 1 1 - 0 (0) 0 0
  Ihosy 1 1 (100) - - - - 1 - 0 (0) 0 0
West Miandrivazo 60 50 (83) 1 1 - 43 47 44 2 (3) 1 1
  Maevatanana 22 14 (64) - 2 5 12 12 - 8 (36) 8 0
Central Highlands Tdd 59 42 (71) 1 4 - 33 37 6 11 (19) 11 0
  Moramanga 5 3 (60) - 1 - 2 2 - 3 (60) 3 0
East Farafangana 1 1 (100) - - - 1 1 - 1 (100) 1 0
Total   159 113 (71) 2 (1.3) 9 (5.7) 5 (3.1) 92 (57.9) 101 (63.5) 50 (31.4) 25 (16) 24 (15) 1 (0.6)
  1. Residues displaying new mutations are indicated in bold typeface
  2. Tdd: Tsiroanomandidy