Table 3 Frequency distribution of pvdhfr/pvdhps genotypes in 159 Malagasy isolates collected from 7 sites in 2006–2007
Sampling sites | |||||||||
|---|---|---|---|---|---|---|---|---|---|
dhfralleles | dhps alleles | South | West | Central Highlands | East | Total isolates (frequency %) | |||
Ejeda | Ihosy | Maevatanana | Miandrivazo | Tdd | Moramanga | Farafangana | |||
No mutation | |||||||||
Wild-type | Wild-type | 9 | - | 7 | 10 | 17 | 1 | - | 44 (27.7) |
383G | - | - | 1 | - | - | 1 | - | 2 (1.3) | |
Single mutant | |||||||||
21S | Wild-type | - | - | - | 1 | 1 | - | - | 2 (1.3) |
33L | Wild-type | 1 | - | 2 | - | 4 | 1 | - | 8 (5.0) |
117N | Wild-type | - | 1 | - | 3 | 3 | - | - | 7 (4.4) |
130K | Wild-type | - | - | - | 1 | - | - | - | 1 (0.6) |
Double mutant | |||||||||
33L + 130K | Wild-type | - | - | - | 1 | - | - | - | 1 (0.6) |
117N + 130K | Wild-type | - | - | - | 1 | 1 | - | - | 2 (1.3) |
58R + 117N | Wild-type | 1 | - | 4 | 2 | 18 | - | - | 25 (15.7) |
383G | - | - | 3 | - | 10 | 2 | 1 | 16 (10.1) | |
Triple mutant | |||||||||
49R + 58R + 117N | Wild-type | - | - | 1 | - | - | - | - | 1 (0.6) |
383G | - | - | 4 | - | - | - | - | 4 (2.5) | |
Wild-type | - | - | - | 39 | 4 | - | - | 43 (27.0) | |
58R + 117N + 130K | 422R | - | - | - | 1 | - | - | - | 1 (0.6) |
383G | - | - | - | 1 | 1 | - | - | 2 (1.3) | |