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Table 3 Frequency distribution of pvdhfr/pvdhps genotypes in 159 Malagasy isolates collected from 7 sites in 2006–2007

From: Plasmodium vivax dhfr and dhps mutations in isolates from Madagascar and therapeutic response to sulphadoxine-pyrimethamine

   Sampling sites  
dhfralleles dhps alleles South West Central Highlands East Total isolates (frequency %)
  Ejeda Ihosy Maevatanana Miandrivazo Tdd Moramanga Farafangana  
No mutation          
   Wild-type Wild-type 9 - 7 10 17 1 - 44 (27.7)
  383G - - 1 - - 1 - 2 (1.3)
Single mutant          
   21S Wild-type - - - 1 1 - - 2 (1.3)
   33L Wild-type 1 - 2 - 4 1 - 8 (5.0)
   117N Wild-type - 1 - 3 3 - - 7 (4.4)
   130K Wild-type - - - 1 - - - 1 (0.6)
Double mutant          
   33L + 130K Wild-type - - - 1 - - - 1 (0.6)
   117N + 130K Wild-type - - - 1 1 - - 2 (1.3)
   58R + 117N Wild-type 1 - 4 2 18 - - 25 (15.7)
  383G - - 3 - 10 2 1 16 (10.1)
Triple mutant          
   49R + 58R + 117N Wild-type - - 1 - - - - 1 (0.6)
  383G - - 4 - - - - 4 (2.5)
  Wild-type - - - 39 4 - - 43 (27.0)
   58R + 117N + 130K 422R - - - 1 - - - 1 (0.6)
  383G - - - 1 1 - - 2 (1.3)