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Table 2 Prevalence and associated case fatality rates of different signs on admission in malaria patients

From: Malaria in rural Mozambique. Part II: children admitted to hospital

  Prevalence among total malaria patients CFR in total malaria patients Prevalence among severe malaria patients CFR in severe malaria patients
  % (n/N) 95% CI % (n/N) 95% CI % (n/N) 95% CI % (n/N) 95% CI
Commonly used criteria for severe malaria
Severe Anaemia (PCV < 15%) 4.6% (187/4027) 4.0–5.3 5.7% (9/159) 2.6–10.5 17.3% (187/1082) 15.1–19.7 5.7% (9/159) 2.6–10.5
Deep Coma (BCS ≤ 2) 0.6% (24/4078) 0.4–0.9 18.2% (4/22) 5.2–40.3 2.2% (24/1099) 1.4–3.2 18.2% (4/22) 5.2–40.3
Repeated (≥2/24 h) convulsions 2.4% (98/4076) 2.0–2.9 4.4% (4/91) 1.2–10.9 8.9% (98/1099) 7.3–10.8 4.4% (4/91) 1.2–10.9
Hypoglycaemia (<2.2 mmol/L) 1.0% (40/3904) 0.7–1.4 16.2% (6/37) 6.2–32.0 3.7% (39/1046) 2.7–5.1 16.2% (6/37) 6.2–32.0
Prostration 14.9% (607/4080) 13.8–16.0 5.1% (29/564) 3.5–7.3 55.0% (605/1100) 52.0–58.0 5.2% (29/563) 3.5–7.3
Respiratory distress 11.1% (454/4076) 10.2–12.1 6.1% (25/407) 4.0–8.9 41.1% (452/1100) 38.2–44.1 6.2% (25/405) 4.0–9.0
Other Signs
Impaired consciousness (BCS < 5) 2.1% (86/4078) 1.7–2.6 10.0% (8/80) 4.4–18.8 6.5% (71/1099) 5.1–8.1 12.3% (8/65) 5.5–22.8
Jaundice 1.2% (47/4076) 0.8–1.5 0% (0/43) - 1.9% (21/1100) 1.2–2.9 0% (0/20) -
Transfusion recipients 14.4% (586/4065) 13.3–15.5 2.8% (16/568) 1.6–4.5 29.1% (320/1099) 26.4–31.9 4.5% (14/310) 2.5–7.5
Dehydration (mod./sev.) 3.4% (139/4076) 2.9–4.0 6.2% (8/129) 2.7–11.9 5.8% (64/1100) 4.5–7.4 10.3% (6/58) 3.9–21.2
Number of severity criteria*
Only one      78.4% (808/1031) 75.7–80.8 3.0% (23/762) 1.9–4.5
Two      16.6% (171/1031) 14.4–19.0 8.3% (12/145) 4.3–14.0
Three      4.2% (43/1031) 3.0–5.6 13.2% (5/38) 4.4–28.1
Four or more      0.9% (9/1031) 0.4–1.7 42.9% (3/7) 9.9–81.6
Parasitaemia on admission (parasites/μL)
1 to 4,999 20.8% (848/4080) 19.5–22.1 2.2% (17/788) 1.3–3.4 25.7% (283/1100) 23.2–28.4 4.2% (11/259) 2.1–7.5
5,000 to 19,999 17.5% (713/4080) 16.3–18.7 2.0% (13/666) 1.0–3.3 17.7% (195/1100) 15.5–20.1 6.2% (11/177) 3.1–10.8
20,000 to 99,999 43.7% (1783/4080) 42.2–45.2 1.3% (22/1695) 0.8–2.0 40.3% (443/1100) 37.4–43.2 3.9% (16/411) 2.2–6.2
≥ 100,000 18.0% (736/4080) 16.9–19.3 1.4% (10/710) 0.7–2.6 16.3% (179/1100) 14.1–18.6 4.1% (7/169) 1.7–8.3
  1. * Any of the following: Severe anaemia, deep coma, repeated convulsions, hypoglycaemia, prostration or respiratory distress