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Table 1 Baseline characteristics of study sites and patients at enrolment

From: The usefulness of twenty-four molecular markers in predicting treatment outcome with combination therapy of amodiaquine plus sulphadoxine-pyrimethamine against falciparum malaria in Papua New Guinea

 

Study site

Characteristics

Karimui area (Simbu Province)

South Wosera (East Sepik Province)

Study sites

n = 80

n = 94

Endemicity*

mesoendemic

mesoendemic

Transmission intensity§

moderate

high

Patients

  

Weight (mean (95% CI), kg)

13.8 (12.9–14.6)

14.4 (13.8–15.1)

Age (mean (95% CI), yrs)

4.0 (3.7–4.4)

4.5 (4.2–4.8)

Sex: female/n (%)

43/97 (44.3)

59/112 (52.7)

Temperature (mean (95% CI),°C)

38.7 (38.5–38.9)

38.7 (38.4–39.0)

Haemoglobin (mean (95% CI), g/dl)

9.0 (8.6–9.5)

9.0 (8.7–9.3)

Parasite density (geometric mean (range), per μl)

21937 (1120–329400)

40526 (280–774400)

Multiplicity of infection (= MOI) (mean (95% CI))

1.48 (1.34–1.63)

1.73 (1.59–1.88)

Spleen rate# (% (95% CI))

43.3 (33.3–53.7)

50.9 (41.3–60.5)

  1. * Assessed by concomitant cross-sectional surveys in both study areas which showed P. falciparum prevalence rates of 11–50% in children aged 2–9 years (WHO, 2003); § Müller et al., 2003; # proportion of children with enlarged spleen