From: Clinically immune hosts as a refuge for drug-sensitive malaria parasites
Acquisition of clinical immunity | θ-1 | 10 years |
Loss of clinical immunity | γ-1 | 2 years |
Fraction of new infections that are treated and cleared | ξ1 | 0.3 |
ξ2 | 0.01 | |
Rate clinical symptoms arise (σ i ) times Fraction treated (f i ) equals rate existing infections are cleared by drugs (ρ i ) | σ1f1 = ρ1 | 0.025(0.2) = 1/200 |
σ2f2 = ρ2 | 0.01(0.2) = 1/500 | |
Disease induced death rate | m | 180/100000/year |
Human feeding rate | α | 0.3 |
Infectivity rate | b | 0.8 |
Mosquito death rate | g | 1/10 |
Number of days required for sporogony | n | 10 |
Recovery rate | r w | 1/(165/b) |
r x | r w (fitness cost) |