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Figure 1 | Malaria Journal

Figure 1

From: The severity of malarial anaemia in Plasmodium chabaudi infections of BALB/c mice is determined independently of the number of circulating parasites

Figure 1

Comparison of anaemia and peak parasitaemia in P. chabaudi (AS) infected recombinase activating gene 2 -/- (RAG2-/-) and BALB/c mice. a) Peak number of circulating pRBCs measured over the first 9 days of infection; b) Drop in the number of circulating RBCs and c) Drop in Hb level of the blood relative to day 0 measurements in BALB/c and BALB/c RAG2-/- animals. The bars in a) to c) represent the average, and the error bars the SEM, of the cumulative values of 15 BALB/c AS-infected animals (black square) 15 RAG2-/- AS- infected animals (open square) from 3 experiments. d) and e) Residual amount of anaemia (once experiment has been taken into account) in P. chabaudi infection of BALB/c mice (black circle) and RAG2-/- mice plotted (open circle) against the peak number of circulating pRBCs for each mouse. In d) and e) the solid line represents the best-fit linear regression line. The dashed line highlights the residual anaemia observed once the data is normalized for experimental variation in the magnitude of RBC loss (ANOVA model "RBC loss = experiment"). Therefore the solid best-fit regression line shows the extent to which peak pRBC numbers correlate with the drop in circulating RBCs once experiment has been accounted for (residual change in RBC number). The black dots represent BALB/c animals and the white dots represent RAG2-/- animals.

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