Impact of community-based presumptive chloroquine treatment of fever cases on malaria morbidity and mortality in a tribal area in Orissa State, India
© Das et al; licensee BioMed Central Ltd. 2008
- Received: 06 November 2007
- Accepted: 05 May 2008
- Published: 05 May 2008
In the Global Strategy for Malaria Control, one of the basic elements is early detection and prompt treatment of malaria cases, especially in areas where health care facilities are inadequate. Establishing or reviving the existing drug distribution centers (DDC) at the peripheral levels of health care can achieve this. The DDCs should be operationally feasible, acceptable by community and technical efficient, particularly in remote hard-core malaria endemic areas.
Volunteers from villages were selected for distribution of chloroquine and the selection was made either by villagers or head of the village. The services of the volunteers were absolutely free and voluntary in nature. Chloroquine was provided free of charge to all fever cases. The impact was evaluated based on the changes observed in fever days, fever incidence, parasite incidence and parasite prevalence (proportion of persons harbouring malaria parasite) in the community. Comparisons were made between 1st, 2nd and 3rd year of operation in the experimental villages and between the experimental and check areas.
A total of 411 village volunteers in 378 villages in the experimental community health center with a population of 125,439 treated 88,575 fever cases with a mean annual incidence of 331.8 cases per 1,000 population during the three-year study period. The average morbid days due to fever (AFD) was reduced to 1.6 ± 0.1 from 5.9 ± 2.1 in the experimental villages while it remained at 5.0 ± 1.0 in the check villages. There was a significant reduction, (p < 0.05) in Annual Fever Incidence (AFI) in the experimental hilltop and foothill villages in comparison to check villages. The change in Annual Parasite Incidence (API) was, however, not statistically significant (p > 0.05). In plain villages that were low endemic, the reductions in AFI and API in experimental villages were statistically significant (p < 0.05). There was significant reduction in the parasite prevalence in high endemic villages of the experimental area both during 2nd and 3rd year when compared with the check area (p < 0.05) but no such reduction was observed in low endemic areas (p > 0.0.5). Mortality due to malaria declined by 75% in the experimental villages in the adult age group whereas there was an increasing trend in check villages.
The study demonstrated that a passive chloroquine distribution system operated by village volunteers in tribal areas is feasible and effective in reducing malaria-related morbidity and mortality.
- Experimental Area
- Community Health Centre
- Parasite Prevalence
The present strategies for malaria control vary depending up on the epidemiological situations. Until a safe, effective and affordable vaccine against malaria is available, its control will depend on antimalarial drugs and measures for reduction in man-vector contact. Malaria remains a major public health problem in India and about three million clinical cases are recorded every year. The incidence of Plasmodium falciparum has shown an increasing trend, a major proportion of cases being recorded from hilly and forested regions of the country . Health care facilities are inadequate in these areas and death from malaria is common . The Government of India has implemented a three-pronged strategy, under the Modified Plan of Operation (MPO) in 1977, with an emphasis on early case detection and treatment to reduce mortality from malaria. Drug Distribution Centers (DDCs) were established at village level and they are manned by a village health guide (VHG) . The programme was integrated with the primary health care delivery system. The functioning of DDCs deteriorated due to lack of proper supervision, short supply of drugs, influence of local politics in selecting the VHGs, and the poor and irregular remuneration of VHGs (Rs.50, approx. US $1, per month). This resulted in defunct DDCs. Neither the functioning of DDCs and VHGs were evaluated on time nor any modifications to operational strategies were made for effective implementation.
In the Global Strategy for Malaria Control, one of the basic elements is early detection and prompt treatment , especially in areas where health care facilities are inadequate. National Programme in India is now laying emphasis on reviving the drug distribution system under various health schemes. Therefore, there was a need to establish DDCs or revive the existing ones, evaluate the operational feasibility, community acceptability and technical efficiency of the system, particularly in remote areas. This communication presents the results of a study undertaken to assess the feasibility of establishing drug distribution centres through village volunteers in a tribal area, where health-seeking practice of the community has been poor. The impact of treatment of fever cases with chloroquine (10 mg/kg. body wt., single dose) on morbidity, mortality and parasite prevalence in community were assessed.
Choroquine sensitivity status of Plasmodium falciparum in the study area
Selection of village volunteers
One volunteer from each village was selected for distribution of chloroquine and the selection was made either by villagers or head of the village. The volunteers were imparted training on diagnosis based on the symptoms of malaria and on chloroquine administration as prescribed in the National Anti-Malaria Programme through group discussion sessions and demonstrations.
Volunteers were advised to provide chloroquine to those patients who approach them for treatment and to fill up a 'fever treatment sheet' indicating the name, age, sex, number of days suffering from fever and the number of chloroquine tablets given. Those volunteers with no educational background were supplied with pre-packed chloroquine tablets in colored disposable plastic pouches for different age classes. The number of suspected malaria cases treated by age class was counted from number and type of pouches available with the volunteer at any point of time. Chloroquine was provided free of cost to patients. The volunteers were neither paid nor remunerated in kind.
The fever treatment sheets were collected from the volunteers after replenishment of chloroquine tablets through nine field workers located at different centres of the CHC area at fortnightly interval. Some Anganwadi workers of Integrated Child Development Scheme (ICDS) of the state Government also served as chloroquine distributors in addition to village volunteers to have better accessibility of all sections of people of the village.
The impact was evaluated based on the changes observed in fever days (the average number of days a patient suffered from fever before treatment), fever incidence (number of fever cases/year/1,000), malaria parasite incidence (number of microscopically proved malaria cases/year/1,000) and parasite prevalence (proportion of persons harbouring malaria parasite) in the community. Fever incidence in experimental area was calculated from the total number of cases receiving treatment from DDCs or Anganwadi centres. Malaria incidence was determined from the fortnightly fever surveillance carried out from 47 randomly selected villages (10% of the total population) in the experimental area. The finger prick blood slides were stained with Giemsa and 100 fields in each thick film were examined with 100× magnification . Surveillance records of the CHC were used to determine fever and malaria incidence in the check area. Cross sectional sample blood surveys were carried out following identical methodologies in both the experimental and check areas at pre-intervention and six monthly during intervention (cold and dry season) to know the impact on the malaria parasite prevalence in the community. The villages to be sampled were selected following random number sampling design so as to cover 10 % of the total population from each endemic zone.
The number of fever cases not taking treatment from volunteers was identified through door-to-door surveys in randomly selected villages every fortnight. The patients were interviewed to know the reason for not seeking treatment from DDCs.
Comparison of impact of fever incidence, parasite incidence and parasite prevalence was made between 1st, 2nd and 3rd year of operation in the experimental villages and between the experimental and check CHCs. The odds ratio test was used to compare the change in fever and parasite incidence between experimental and check villages during 1st and after 3rd year of intervention.
Information on the deaths attributed to malaria was collected from the records available at the check and experimental CHCs. However, there is a wide spectrum severe and complicated manifestation of falciparum malaria reported from this area .
Performance of volunteers
Population, volunteers, DDCs and FTDs in high and low endemic villages
Anganwadi workers & centres
No. of * Village Volunteers
Total no. of DDCs
No. of FTDs
Majority of the volunteers administered chloroquine as per the age class dosage schedule and maintained records properly. About 10% of the volunteers were replaced at different points of time as they were losing interest and were not performing well. The majority (64%) of volunteers reported having participated in drug distribution for social recognition.
Reported reasons for not receiving treatment from DDCs
No. of villages/DDCs surveyed
No. of fever cases interviewed
No. of cases not received treatment from DDCs
1. Unaware of DDCs
2. No relief with chloroquine treatment
3. Prefer injections
4. Unwilling to get treatment for infants
5. Negligence, waiting to be relieved from fever
6. Prefer to take medicines from PHC/ANM/MPW
7. Absence of volunteers at time of visit
8. Unwilling to take treatment for women who have delivered
9. Belief that tablets reduce fever in day time only
10. Volunteer was from a lower caste
11. No one to help to approach DDCs
12. No trust in DDCs
13. Prefer sugar coated tablets
14. No stock of tablets with the volunteer at the time of visit
Impact on fever incidence
Impact on parasite incidence
In high endemic villages, the API reduced by 63.1% during the 2nd year followed by an increase of 66.6% during the 3rd year in experimental villages, whereas the reduction was 21.2% followed by an increase of 24% during the corresponding period in the check villages. The overall reduction observed in API at the end of 3rd year was not significantly different (χ2 = 1.46, P > 0.05)) between the experimental and check villages. No definite month-wise pattern was observed in monthly parasite incidence in the high endemic villages of the experimental area (Figure 3B).
In low endemic villages, the API was reduced by 56.8% during the 2nd year in experimental villages, whereas in the control villages the percentage of reduction was only 3.4%. However, during the 3rd year there was a marginal increase of 14% in API in the experimental villages when compared to an increase of 79.9% in the control villages. The overall reduction observed in API at the end of 3rd year was significantly different (χ2 = 40.14, P < 0.05)) between the experimental and check villages. Though no definite month-wise pattern was observed in monthly parasite incidence, there was declining trend in the low endemic villages of the experimental area (Figure 3B).
Impact on parasite prevalence
The pre-intervention parasite prevalence in dry season (month of May) was 3.2% and 3% in low endemic check and experimental areas respectively. There was a marginal increase in the parasite prevalence during the cold season (month of December) during the 1st year in both the check (4%) and experimental (3.4%) areas. However, there was no significant reduction (P > 0.05) in the prevalence in the experimental area both dry and cold during 2nd and 3rd year when compared with the check area (Figures 4B and 4D).
Impact on morbidity days
The average number of fever days (AFD) during the pre-control period was 5.9 and 4.8 in the experimental and control villages respectively. It reduced to 1.6 in the experimental study area where as it remained at five in the check areas.
Impact on mortality due to malaria
Age group-wise number of deaths due to malaria in the high endemic experimental and check CHCs.
Age group (In years)
Pre-intervention period (one year)
Intervention period Cumulative (for 3 years)
Post-intervention period (one year)
10 & above
This was the first study involving village volunteers for the treatment of fever cases in India covering a population of more than one lakh (one hundred thousand) in a tribal area known to be hyper-endemic for P. falciparum malaria for decades. The study has shown that trained community volunteers were able to provide treatment to suspected malaria cases. It has also demystified the misconception that, in tribal areas, people have faith in traditional treatments only. Many of them adopt their native remedies and witchcraft, as the chloroquine treatment was not readily available to them. The timely treatment provided by community volunteers was acceptable to the community. Therefore, it can be concluded that it is feasible to establish and sustain DDCs in tribal areas, provided proper training and logistic support is ensured. Malaria surveillance and treatment using community volunteers had been successful in different epidemiological settings [10–13]. However, in the Philippines, the involvement of volunteers could not contribute optimally because of inadequate training, lack of logistic support, poor sustainability of motivational schemes and lack of community support.
Data on malarial mortality suggest that there was a reduction of malarial deaths in the experimental villages in comparison to the check villages. The impact was visible in the 10–14 and >= 15 year age classes. Although the results on malaria deaths have to be judged with caution because of under-reporting, they give, nevertheless, a definite trend of lower death rates attributable to fever in the study area in comparison to control area. Data from hospital admissions of severe cases indicated that the proportion of patients admitted with history of fever reduced from 76% (one out of 13) at the beginning of the study to 33% within two years (one out of 30) and thus suggesting that many cases were treated at the village. The present study also showed that in high endemic villages the strategy could not reduce malaria incidence and prevalence. The reduction during the 2nd year was most probably due to the additional effect of residual insecticide spraying with DDT by the state government. Additionally, vector control measures are required in these areas for transmission reduction.
In low endemic villages, treatment of suspected fever cases through DDCs reduced malaria incidence, but not prevalence during three-year study period. It may take a longer period to liquidate the parasite reservoir in these areas. However, since only 19% of the total fever cases recorded in the villages were malaria positives, opening DDCs in these low endemic areas may result in excessive distribution of chloroquine. Therefore, emphasis could be on opening fever treatment centres apart from the regular fever surveillance and prompt radical treatment of parasite positive cases. Presumptive treatment of fever cases with chloroquine of 10 mg/kg single dose has a definite effect in reducing the morbid days due to fever and reduction in the number of malaria related deaths and villagers were willing to participate in the treatment system provided the supply of chloroquine was on time and regular.
The authors acknowledge the help rendered by the Department of Health and Family Welfare, Government of Orissa, India by supplying chloroquine tablets, free of cost for the study and for providing CHC data on malaria. The authors also acknowledge the constant encouragement given by Dr. P.K. Das, former Director of Vector Control Research Centre (VCRC), Pondicherry, during the entire study period. The technical assistance rendered by VCRC field station staff at Jeypore, Orissa is duly acknowledged. Indian Council of Medical Research (ICMR), New Delhi, funded the project.
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- Sharma RS, Sharma GK, Dhillon GPS: Epidemiology and control of malaria in India. 1996, Directorate of National Malaria Eradication Programme, New-Delhi, India, 206-208.Google Scholar
- Rajagopalan PK, Das PK: Primary health care. Theory and practice in the Indian context. Indian Council of Medical Research Bulletin. 1988, 18: 55-59.Google Scholar
- World Health Organization: Implementation of the Global Malaria Control Strategy. Report of a WHO study group on the implementation of the global plan of action for malaria control. WHO Technical Report Series. 1993, 839: 1-24.Google Scholar
- Rajagopalan PK, Das PK, Jambulingam P, Mohapatra SS, Gunasekaran K, Das LK: Parasitological aspects of malaria persistence in Koraput district of Orissa, India. Indian J Med Res. 1990, 91: 44-51.PubMedGoogle Scholar
- Jambulingam P, Mohapatra SS, Goverdhini P, Das Lalit Kumar , Manoharan A, Pani SP, Das PK: Microlevel epidemiological variations in malaria & its implications on control strategy. Indian J Med Res. 1990, 93: 371-378.Google Scholar
- Mohapatra SS, Das LK, Pani SP: Chloroquine sensitivity of P. falciparum in Koraput district, Orissa. Indian J Malariol. 1989, 26: 355-364.Google Scholar
- Das LK, Sahu SS: A short note on present trend of chloroquine sensitivity of P. falciparum in Malkangiri district of Orissa state. Indian J Malariol. 1996, 33: 48-51.PubMedGoogle Scholar
- Bruce Chwatt LJ: Essential Malariology. 1985, William Heinmann Medical Books Ltd., London, 85-126.Google Scholar
- Das LK: Spectrum of severe and complicated manifestations of falciparum malaria in Koraput district, Orissa state. The National Medical Journal of India. 2000, 14: 120-121.Google Scholar
- Ghebreyesus TA, Alemayehu T, Bosman A, Witten KH, Teklehaimanot A: Community participation in malaria control in Tigray region, Ethiopia. Acta Trop. 1996, 61: 145-156. 10.1016/0001-706X(95)00107-P.View ArticlePubMedGoogle Scholar
- Rahman SH, Mohamedani AA, Mirgani EM, Ibrahim AM: Gender aspects and women's participation in the control and management of malaria in Sudan. Soc Sci Med. 1996, 42: 1433-1446. 10.1016/0277-9536(95)00292-8.View ArticleGoogle Scholar
- Ruebush II, Trenton K, Zeissig , Rodolfo , Robert Klein, Hector Godoy: Community participation in malaria, surveillance and treatment II. Evaluation of volunteer collaborator network of Guatemala. Am J Trop Med Hyg. 1992, 46: 261-271.PubMedGoogle Scholar
- Spencer HC, Kaseje DC, Roberts JM, Huong AY: Consumption of chloroquine phosphate provided for treatment of malaria by volunteer village health workers in Saradidi, Kenya. Ann Trop Med Parasitol. 1987, 81 (Suppl 1): 116-123.PubMedGoogle Scholar