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Table 1 Frequency of haplotypes in different subsets of the host population

From: Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population

         

adults vs. children

adults vs. new infections

Haplotype 1

Adults cross section 2 (n = 61)

Children cross section 2 (n = 63)

TRS 3 baseline samples (n = 109)

TRS 3 new infections (n = 144)

OR

p 4

95% CI

OR

p 4

95% CI

 

n

%

n

%

n

%

n

%

      

crt 76 crt 326 crt 356

0

0

0

0

0

0

1

0.69

-

-

-

-

-

-

crt 76 crt 326 crt 356 crt 220

1

1.64

1

1.59

0

0

0

0

0.97

0.98

0.06 – 15.83

-

-

-

crt 76 crt 326 crt 356 dhfr 108 dhfr 59

0

0

0

0

3

2.75

0

0

-

-

-

-

-

-

crt 76 crt 326 crt 356 crt 220 dhps 540

0

0

1

1.59

  

0

0

-

-

-

-

-

-

crt 76 crt 326 crt 356 crt 220 mdr 86

4

6.56

2

3.17

0

0

1

0.69

0.47

0.39

0.08 – 2.65

0.1

0.04

0.01 – 0.91

crt 76 crt 326 crt 356 crt 220 dhfr 108 dhfr 59

3

4.92

0

0

4

3.67

1

0.69

-

-

-

0.14

0.09

0.01 – 1.33

crt 76 crt 326 crt 356 dhfr 108 dhfr 59 mdr 86

8

13.11

4

6.35

15

13.76

8

5.56

0.45

0.21

0.13 – 1.58

0.39

0.07

0.14 – 1.09

crt 76 crt 326 crt 356 crt 220 dhfr 108 mdr 86

1

1.64

2

3.17

2

1.83

2

1.39

1.97

0.59

0.17 – 22.27

0.85

0.89

0.75 – 9.5

crt 76 crt 326 crt 356 dhfr 108 dhfr 59 mdr 86 dhps 540

0

0

0

0

0

0

1

0.69

-

-

-

-

-

-

crt 76 crt 326 crt 356 crt 220 dhfr 108 dhfr 59 mdr 86

40

65.57

53

84.13

85

77.98

126

87.5

2.78

0.02

1.18 – 6.56

3.68

0.001

1.78 – 7.57

crt 76 crt 326 crt 356 crt 220 dhfr 108 dhfr 59 mdr 86 dhps 540

2

3.28

0

0

0

0

4

2.78

-

-

-

0.84

0.85

0.15 – 4.73

crt 76 crt 326 crt 356 crt 220 dhfr 108 dhfr 59 mdr 1042 mdr 184

1

1.64

0

0

0

0

0

0

-

-

-

-

-

-

crt 76 crt 326 crt 356 crt 220 dhfr 108 dhfr 59 mdr 86 dhps 437

1

1.64

0

0

0

0

0

0

-

-

-

-

-

-

  1. 1) Haplotypes represent 11 single nucleotide polymorphisms (SNPs) in 4 different genes. The remaining 14 SNPs tested but not listed equal to wildtype.
  2. 2) Cross-sectional samples include only individuals that have not been treated with antimalarial drugs in the 2 months prior to the survey.
  3. 3) TRS, treatment to reinfection study
  4. 4) Bold indicates p < 0.05
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Malaria Journal

ISSN: 1475-2875

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