Figure 1

Log plasma biomarker levels and disease severity. Log median levels (pg/ml) of twelve (12) biomarkers [sTNF-R1, sTNF-R2 IL-1ra, sFas, Fas-L, IP-10, MIP-1β, IL-8, IL-10, VEGF, PDGFbb and FGF basic protein]. With the exception of sFas, Fas-L, sTNF-R1, and sTNF-R2 that were measured by ELISA, all other biomarkers were quantified via Luminex™ from blood samples collected from patients at time of admission. HC – healthy controls, MM – mild malaria, CMS – cerebral malaria survivors, CMNS – cerebral malaria non-survivors. Box plots represent medians and 25^th and 75^th percentiles. Bars mark the 10^th and 90^th percentiles, and outliers are plotted as points. HC versus MM, CMS, and CMNS: *** p < 0.05, $$$ p < 0.0045 bonferroni adjustment (alpha = 0.05/12)