Genetic diversity of vaccine candidate antigens in Plasmodium falciparum isolates from the Amazon basin of Peru

Malaria Journal

Table 2 Alleles found in Peruvian isolates.

Gene	Allele	Amino acid sequences
Pfcsp		326	Th2R	342			367	Th3R	378
	3D7	P S D K H I K E Y L N K I Q N S L					N K P K D E L D Y A N D
	1	. . . . . . E Q . . K . . K . . I					. . . . . . . . . E . .
	2	. . . . . . E Q . . K . . . . . .					G . S . . . . . . E . .
	3	. . . . . . E Q . . K . . . . A .					. . . . . Q . . . E . .
	4	. . . Q . . E K . . Q . . R . . .					. . . . . Q . N . E . .
Pfmsp-1		Block 2					Block 17
							1644	1691	1700	1701	1716
	3D7	SAQSGASAQSGASAQSGASAQSGASAQSGASAQSGTSGPSGPSGT					E	T	S	R	L
	1	SAQSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGPSGPSGT					Q	K	N	G	f
	2	SGGSVTSGGSGGSGGSGGSGGSVASGGSVASGGSGGSVASGGSVASGG					Q	K	N	G	f
	3	SAQSGASAQSGASAQSGASAQSGTSGPSGPSGT					Q	K	N	G	f
	4	SAQSGTSGTSGPSGTSGPSGTSGPSGTSGPSGTSGPSGT					Q	K	N	G	f
	5	SAQSGASAQSGASAQSGASAQSGASAQSGTSGPSGPSGT					Q	K	N	G	f
	6	SGGSVTSGGSGGSGGSGGSVASGGSVASGGSGGSVASGGSVASGG					Q	K	N	G	f
	7	SAQSGTSGTSGTSGTSGTSGPSGPSGT					Q	K	N	G	f
Pfama-1		259	R1	271			279	R2	287
	3D7	G P R Y C N K D E S K R N					A K D I S F Q N Y
	1	. . . . . . . . . . . . .					. . . . . . . . .
	2	. . . . . . . . Q . . . .					. . . K . . . . .
	3	. . . . . . . . . . . . .					. . . K . . . . .
Pflsa-1		84	T1	107
	3D7	L T M S N V K N V S Q T N F K S L L R N L G V S
	1	. S . . . . . . . . . . . . . . . . . . . . . .
	2	. S . . . . . . . . . . Y . . . . . . . . . . .
	3	. . . . . . . . . . . . . . . . . . . . . . . .
Pfssp-2		P1		P2		P3		P4		P5
		79	88	201	215	421	435	461	475	504	513
	3D7	NLNDNAIHL		FLVGHPSDGKCNLY		NDKSDRYIPYSPLSP		SEDRETRPHGRNNENRSY		GLALLACAGLAY
	1	...E....		.............		.............P.		..................		............

Amino acids sequences for major T and B cell epitopes in vaccine candidate antigens from Peruvian isolat

ISSN: 1475-2875