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Table 4 Haplotypes defined by allelic variants (1–7) of four antigens MSP-1-B2:CSP:AMA-1:LSA-1 (respectively), comparing the 1998–99, 2003–05 and 2006 study-years.

From: Genetic diversity of vaccine candidate antigens in Plasmodium falciparum isolates from the Amazon basin of Peru

Haplotypes

MSP-1:CSP:AMA-1:LSA-1

All

1998–99

2003–05

2006

1111

46

36.2%

19

40.4%

6

21.4%

21

42.0%

1112

5

3.9%

4

8.5%

1

3.6%

0

0.0%

1131

1

0.8%

0

0.0%

0

0.0%

1

2.0%

1211

6

4.7%

0

0.0%

5

17.9%

1

2.0%

1212

2

1.6%

0

0.0%

2

7.1%

0

0.0%

2111

3

2.4%

0

0.0%

1

3.6%

2

4.0%

2112

16

12.6%

14

29.8%

1

3.6%

1

2.0%

2121

1

0.8%

1

2.1%

0

0.0%

0

0.0%

2122

3

2.4%

2

4.3%

1

3.6%

0

0.0%

2211

20

15.7%

0

0.0%

4

14.3%

16

32.0%

2212

2

1.6%

1

2.1%

1

3.6%

0

0.0%

2422

1

0.8%

1

2.1%

0

0.0%

0

0.0%

3121

6

4.7%

0

0.0%

4

14.3%

2

4.0%

3211

1

0.8%

0

0.0%

0

0.0%

1

2.0%

3212

1

0.8%

0

0.0%

1

3.6%

0

0.0%

4212

1

0.8%

0

0.0%

0

0.0%

1

2.0%

4231

3

2.4%

0

0.0%

0

0.0%

3

6.0%

5121

1

0.8%

1

2.1%

0

0.0%

0

0.0%

5212

1

0.8%

1

2.1%

0

0.0%

0

0.0%

5323

1

0.8%

0

0.0%

0

0.0%

1

2.0%

5211

1

0.8%

1

2.1%

0

0.0%

0

0.0%

5221

1

0.8%

1

2.1%

0

0.0%

0

0.0%

6111

1

0.8%

0

0.0%

1

3.6%

0

0.0%

7111

1

0.8%

1

2.1%

0

0.0%

0

0.0%

N =

125

 

47

 

28

 

50

 

Count of haplotypes =

24

 

12

 

12

 

11

Haplotype diversity (Hd) =

0.7932

 

0.6910

 

0.8466

 

0.7543

Hd standard deviation =

0.028

 

0.055

 

0.033

 

0.045