Table 3 Regional distribution of pfcrt and pfmdr 1 genotypes
From: Therapeutic efficacy of artemether-lumefantrine in uncomplicated falciparum malaria in India
Isolates, no. (%) | ||||
|---|---|---|---|---|
Genes | Genotypes | Assam (n = 26) | Orissa (n = 32) | Total (n = 58) |
pfmdr 1 | ||||
Wild-type | N86Y184S1032N1042D1246 | 7 (26.9%) | 11 (34.3%) | 18 (31.03%) |
Single-mutant | Y 86 Y184S1032N1042D1246 | 18 (69.2%) | 18 (56.2%) | 36 (62.06%) |
Single-mutant | N86F 184 S1032N1042D1246 | 1 (3.8%) | 3 (9.3%) | 4 (6.89%) |
pfcrt | Assam (n = 36) | Orissa (n = 27) | Total (n = 63) | |
Wild-type | C72M74N75K76 | 3 (8.3%) | 7 (25.9%) | 10 (15.8%) |
Single-mutant | C72M74N75T 76 | - | 1 (3.7%) | 1 (1.5%) |
Double-mutant | S 72 M74N75T 76 | 7 (19.4%) | 2 (7.4%) | 9 (14.2%) |
Triple-mutant | C72 I 74 E 75 T 76 | 26 (72.2%) | 17 (62.9%) | 43 (68.2%) |