| |
Single pfmdr1 copy number
|
Increased pfmdr1 copy number**
|
p*
|
|---|
| |
Number
|
Mean IC50 (range) nM/l
|
Number
|
Mean IC50 (range) nM/l
| |
|---|
|
Mefloquine
|
73
|
27.9 (2.3 – 132.4)
|
17
|
50.3 (9.6 – 132.9)
|
0.007
|
|
Artesunate
|
80
|
1.6 (0.3 – 11.1)
|
17
|
2.1 (0.6 – 5.6)
|
0.054
|
|
Lumefantrine
|
45
|
21.4 (3.6 – 63.5)
|
5
|
44.1 (25.9 – 79.2)
|
0.006
|
|
Artemether
|
33
|
2.2 (0.2 – 17)
|
7
|
7.6 (0.2 – 42.2)
|
0.143
|
|
Quinine
|
73
|
158.2 (26.1 – 615.9)
|
16
|
172.3 (19.9 – 612.2)
|
0.677
|
|
Chloroquine
|
73
|
235.4 (54.1 – 663.3)
|
16
|
175.6 (71.4 – 331.9)
|
0.085
|
- *Significance level (p) was 0.05. The analysis was tested by Wilcoxon rank-sum (Mann-Whitney) test.
- **The cutoff of pfmdr1 multicopy was 2 copies.
