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Table 1 Correlation between IC50 and pfmdr1 copy number outcome.

From: Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia

 

Single pfmdr1 copy number

Increased pfmdr1 copy number**

p*

 

Number

Mean IC50 (range) nM/l

Number

Mean IC50 (range) nM/l

 

Mefloquine

73

27.9 (2.3 – 132.4)

17

50.3 (9.6 – 132.9)

0.007

Artesunate

80

1.6 (0.3 – 11.1)

17

2.1 (0.6 – 5.6)

0.054

Lumefantrine

45

21.4 (3.6 – 63.5)

5

44.1 (25.9 – 79.2)

0.006

Artemether

33

2.2 (0.2 – 17)

7

7.6 (0.2 – 42.2)

0.143

Quinine

73

158.2 (26.1 – 615.9)

16

172.3 (19.9 – 612.2)

0.677

Chloroquine

73

235.4 (54.1 – 663.3)

16

175.6 (71.4 – 331.9)

0.085

  1. *Significance level (p) was 0.05. The analysis was tested by Wilcoxon rank-sum (Mann-Whitney) test.
  2. **The cutoff of pfmdr1 multicopy was 2 copies.
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Malaria Journal

ISSN: 1475-2875

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