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Table 1 Correlation between IC50 and pfmdr1 copy number outcome.

From: Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia

  Single pfmdr1 copy number Increased pfmdr1 copy number** p*
  Number Mean IC50 (range) nM/l Number Mean IC50 (range) nM/l  
Mefloquine 73 27.9 (2.3 – 132.4) 17 50.3 (9.6 – 132.9) 0.007
Artesunate 80 1.6 (0.3 – 11.1) 17 2.1 (0.6 – 5.6) 0.054
Lumefantrine 45 21.4 (3.6 – 63.5) 5 44.1 (25.9 – 79.2) 0.006
Artemether 33 2.2 (0.2 – 17) 7 7.6 (0.2 – 42.2) 0.143
Quinine 73 158.2 (26.1 – 615.9) 16 172.3 (19.9 – 612.2) 0.677
Chloroquine 73 235.4 (54.1 – 663.3) 16 175.6 (71.4 – 331.9) 0.085
  1. *Significance level (p) was 0.05. The analysis was tested by Wilcoxon rank-sum (Mann-Whitney) test.
  2. **The cutoff of pfmdr1 multicopy was 2 copies.
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