Patterns of co-speciation and host switching in primate malaria parasites

Malaria Journal

Table 1 The results of the TreeFitter analysis under various cost settings and under two different evolutionary hypotheses of primate malaria parasites

Using parasite phylogeny from Figure 1
Event cost settings^a				Cost	Co-divergence	Duplication	Sorting	Switching
0	0	1	2	13^cc	2–3	8–9	1–3	5–6^c
0	1	1	1	13^c	4–4	1–2	0-0	10–12
-1	0	0	0	-8	8-8	1–9	21–93^c	0–8
∞	0	∞	1	7^c	0-0	10-10^b	0-0	7-7^c
0	0	0.5	2	11.5^cc	3-3	9-9	3-3	5-5
0	0	1	1	7^c	0–3	8–10^b	0–1	6–7^c
0	0	2	0.5	3.5^c	0–2	8–10^b	0-0	7-7^c
0	0	2	1	7^c	0–2	8–10^b	0-0	7-7^c
100	0	1	2	14^c	0-0	10-10^b	0-0	7-7^c
0	100	1	2	124	4-4	1-1	0-0	12-12
0	0	100	2	14^c	0–2	8–10^b	0-0	7-7^c
0	0	1	100	51	5-5	12-12	51-51	0-0
Using parasite phylogeny from Additional File 1
Event cost settings^a				Cost	Co-divergence	Duplication	Sorting	Switching
0	0	1	2	11^ccc	4-4^b	8-8	1-1	5-5^cc
0	1	1	1	12^cc	5-5	1–2	0-0	10–11
-1	0	0	0	-8	8-8^c	1–9	20–93^c	0–8
∞	0	∞	1	7^c	0-0	10-10^b	0-0	7-7^c
0	0	0.5	2	10.5^ccc	4-4	8-8	1-1	5-5
0	0	1	1	6^cc	2–4^b	8–9	0–1	5–6^cc
0	0	2	0.5	3^cc	2–3^b	8–9	0-0	6-6^cc
0	0	2	1	6^cc	2–3^b	8–9	0-0	6-6^cc
100	0	1	2	14^c	0-0	10-10^b	0-0	7-7^c
0	100	1	2	122	5-5	1-1	0-0	11-11
0	0	100	2	12^cc	2–3^b	8–9	0-0	6-6^cc
0	0	1	100	51^c	5-5	12-12	51-51^c	0-0

The tests were performed between the consensus tree of primate malaria parasites given in Figure 1 and Additional File 1, and the phylogeny of primate host genus in Figure 2. For each model, overall costs and the reconstructed number of events (expressed as ranges that result in equal total costs) are given.
^aEvent costs are co-divergence (co-speciation), duplication (within-host speciation), sorting (extinction) and switching (host change via lateral transfer), respectively.
^bOverall cost/the number of events significantly exceeds that for randomized trees (^bP < 0.05, ^bbP < 0.01, ^bbbP < 0.001).
^cOverall cost/the number of events is significantly less than that for randomized trees (^cP < 0.05, ^ccP < 0.01, ^cccP < 0.001).

ISSN: 1475-2875