Table 2 Distribution (ng equivalents/tissue gram), half lives, and area under the curve (AUC) of [¹⁴C]-dihydroartemisinin in main organs and tissues of male rats following single intravenous dose at 3 mg/20 μCi/kg and animals were euthanized at 1, 6, 24, 48, 72, 96, and 192 hr after dosing (n = 5).

Blood

936.19

795.07

366.76

252.05

194.59

130.92

118.71

122.13 ± 8.73

45463 ± 6810

1.07

Plasma

591.34

540.83

216.03

93.02

64.70

34.58

22.84

75.57 ± 7.34

20750 ± 1031

0.49

Brain

578.68

326.57

160.11

127.38

138.35

119.67

133.52

72.21 ± 6.33

34189 ± 4885

0.81

Eyes

279.20

239.95

64.78

46.86

51.58

98.06

121.94

75.22 ± 9.40

16519 ± 3048

0.39

Adrenals

5614.75

3451.81

2034.62

3002.03

1630.57

1653.43

1543.60

92.48 ± 44.34

448390 ± 273502

10.59

Fat

1391.80

218.23

80.24

62.09

61.62

43.52

84.86

131.69 ± 21.94

25253 ± 1490

0.60

Muscle

698.14

499.29

171.74

163.19

174.04

92.20

115.14

64.45 ± 13.54

36371 ± 6994

0.86

Lungs

1161.72

1040.99

398.52

305.34

303.10

236.70

221.64

86.19 ± 18.00

85916 ± 12999

2.03

Heart

1512.27

1107.89

647.58

527.3

568.43

377.26

443.20

74.35 ± 25.84

104598 ± 24036

2.47

Spleen

4387.40

3684.97

3061.40

4216.03

4446.65

4464.57

5170.22

114.02 ± 57.67

617495 ± 410768

14.58

Kidneys

4097.87

4502.00

2535.56

2324.72

3286.27

1802.63

1819.89

77.90 ± 8.41

191781 ± 66422

4.53

Liver

4594.85

3516.69

1403.29

1104.94

1503.74

842.90

1270.24

95.18 ± 37.90

172474 ± 85780

4.07

Stomach

1366.22

932.33

464.21

342.30

337.48

229.69

218.27

72.58 ± 12.98

82125 ± 13428

1.94

Stomach Content

36.03

6289.79

22.45

98.12

18.69

11.76

343.37

16.75 ± 16.30

22362 ± 98089

0.53

Large intestine (LI)

1818.56

8394.43

1420.58

562.96

509.29

220.41

304.72

62.53 ± 43.59

70217 ± 25001

1.66

LI Content

2914.59

35567.01

5127.28

2037.53

1426.62

491.66

1333.83

37.20 ± 6.08

588542 ± 104261

13.90

Small intestine (SI)

8155.95

3014.58

821.84

335.42

389.72

235.61

304.12

49.99 ± 34.89

131264 ± 24631

3.10

SI Content

46426.85

11387.30

2283.61

633.61

575.05

176.57

250.03

28.73 ± 9.05

1492988 ± 63053

35.25

Testis

624.14

513.53

176.47

155.78

151.29

123.54

141.04

86.24 ± 40.68

48249 ± 6078

100.00

Total Amounts

87186.55

86023.26

21457.06

16390.68

15831.77

11385.67

13961.18

69.03 ± 22.13

4234952.00

1.14

% total recovery

34.57

34.10

8.51

6.50

6.28

4.51

5.53