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Table 3 Percentages of renal and fecal excretion of total radiolabel following single intravenous administration of [14C] dihydroartemisinin with 25% cremophore EL/0.9% saline formulation at 3 mg/kg to rats (n = 5).

From: Pharmacokinetics, tissue distribution and mass balance of radiolabeled dihydroartemisinin in male rats

Sample time (days)

Urine

Feces

Cage wash

0–0.04

4.18 ± 1.06

  

0.04–0.33

25.49 ± 1.98

1.52 ± 0.58

 

0.33–1.0

14.01 ± 5.11

29.56 ± 11.75

 

1–2

4.78 ± 1.30

6.14 ± 1.71

 

2–3

1.63 ± 0.92

1.64 ± 0.78

 

3–4

0.72 ± 0.19

0.78 ± 0.31

 

4–5

0.57 ± 0.25

0.46 ± 0.09

 

5–6

0.46 ± 0.37

0.15 ± 0.06

 

6–7

0.16 ± 0.02

0.11 ± 0.05

 

7–8

0.09 ± 0.04

0.04 ± 0.04

 

Total

52.09 ± 8.94

40.39 ± 13.22

1.88 ± 2.27

   Ratio of excretion (urine/feces)

1.37 ± 0.39

  

   Balance (% of dose)

94.36 ± 16.71

  

Elimination parameters

   

   Peak height (μg/rat)

234.48 ± 33.74

292.39 ± 150.29

 

   Peak time (days)

0.37 ± 0.06

0.67 ± 0.09

 

   Fast elimination phase (days)

0.32 ± 0.07

0.35 ± 0.11

 

   Slow elimination phase (days)

1.36 ± 0.25

1.29 ± 0.47

 
  1. All values expressed as % of dose, mean ± SD, n = 5.