Time | Total | Free fraction | Glucuronide conjugation | Other conjugation fraction |
---|---|---|---|---|
Plasma (n = 5) | ||||
0 | 0.00 | 0.00 | 0.00 | 0.00 |
0.017 | 3446.38 ± 396.35 | 2253.63 ± 537.31 | 403.87 ± 124.77 | 583.17 ± 155.52 |
0.083 | 2279.43 ± 213.77 | 925.14 ± 226.81 | 413.56 ± 69.46 | 589.70 ± 102.30 |
0.167 | 2090.86 ± 180.56 | 697.05 ± 88.04 | 480.62 ± 49.17 | 818.11 ± 88.12 |
0.25 | 1987.48 ± 378.69 | 685.05 ± 193.99 | 360.93 ± 65.83 | 684.75 ± 161.05 |
0.50 | 1489.58 ± 231.59 | 461.20 ± 56.83 | 305.81 ± 26.23 | 627.62 ± 59.19 |
0.75 | 654.49 ± 87.56 | 157.51 ± 28.11 | 131.60 ± 29.09 | 341.12 ± 66.12 |
1.0 | 514.20 ± 139.37 | 105.36 ± 55.10 | 122.76 ± 36.01 | 348.30 ± 125.91 |
1.5 | 419.48 ± 17.06 | 75.83 ± 9.85 | 74.17 ± 11.64 | 268.16 ± 14.76 |
2 | 589.26 ± 154.02 | 90.58 ± 33.58 | 110.13 ± 44.55 | 407.78 ± 112.11 |
3 | 466.65 ± 82.13 | 74.40 ± 16.25 | 80.73 ± 14.20 | 321.61 ± 69.08 |
6 | 584.41 ± 65.49 | 51.49 ± 15.64 | 49.34 ± 22.19 | 363.63 ± 162.04 |
8 | 481.59 ± 79.35 | 49.44 ± 13.34 | 57.72 ± 13.56 | 388.11 ± 72.73 |
24 | 253.62 ± 78.47 | 14.46 ± 3.15 | 20.04 ± 5.05 | 188.12 ± 47.66 |
48 | 79.17 ± 6.71 | 7.41 ± 3.24 | 8.55 ± 1.68 | 77.07 ± 14.36 |
72 | 64.38 ± 14.66 | 4.89 ± 1.83 | 4.31 ± 1.19 | 48.23 ± 12.74 |
96 | 35.26 ± 6.54 | 2.09 ± 1.39 | 2.25 ± 0.87 | 25.39 ± 7.32 |
192 | 13.48 ± 3.65 | 1.01 ± 0.92 | 0.76 ± 0.72 | 14.49 ± 1.62 |
AUC (ng·h/ml) | 21708 ± 2695 | 2188.2 ± 286.4 | 2177.6 ± 299.6 | 14193.6 ± 6838.7 |
t1/2 (hr) | 15.49 ± 1.64 | 4.01 ± 0.99 | 6.66 ± 1.04 | 20.25 ± 1.32 |
% of total | 100.2 ± 12.68 | 10.08 ± 1.32 | 10.03 ± 1.38 | 79.14 ± 8.22 |
Urine (n = 5) | ||||
0 | 0.00 | 0.00 | 0.00 | 0.00 |
0.04 | 37186.4 ± 8200.9 | 2253.63 ± 113.44 | 1611.28 ± 756.20 | 21546.88 ± 8219.11 |
0.33 | 228363.9 ± 20101.9 | 2693.12 ± 1293.63 | 8359.94 ± 1428.22 | 39881.66 ± 5139.02 |
1.0 | 123776.8 ± 38621.3 | 535.48 ± 339.64 | 732.58 ± 373.98 | 10784.80 ± 6618.73 |
2.0 | 42340.5 ± 8839.2 | 184.08 ± 70.94 | 97.20 ± 50.00 | 2003.77 ± 1218.99 |
3.0 | 14248.3 ± 6958.5 | 86.77 ± 56.02 | 29.60 ± 15.80 | 655.31 ± 605.27 |
4.0 | 6355.5 ± 1351.3 | 43.20 ± 26.91 | 17.54 ± 11.47 | 278.99 ± 208.65 |
5.0 | 4984.6 ± 1922.7 | 35.21 ± 39.14 | 12.70 ± 9.90 | 310.60 ± 306.84 |
6.0 | 4006.4 ± 2925.2 | 22.16 ± 28.94 | 7.77 ± 3.88 | 289.69 ± 338.11 |
7.0 | 1451.9 ± 149.2 | 9.75 ± 4.98 | 6.21 ± 2.92 | 147.26 ± 104.46 |
8.0 | 780.1 ± 344.4 | 5.77 ± 3.86 | 3.28 ± 1.66 | 91.76 ± 59.41 |
AUC (ng·h/ml) | 43624 ± 10214 | 2213.6 ± 933.4 | 5069.3 ± 928.2 | 35657.7 ± 9342.1 |
t1/2 (day) | 1.36 ± 0.25 | 1.25 ± 0.11 | 1.30 ± 0.16 | 1.64 ± 0.11 |
% of total | 98.43 ± 23.38 | 5.11 ± 1.45 | 12.22 ± 3.14 | 82.67 ± 3.96 |