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Figure 1 | Malaria Journal

Figure 1

From: T-cell epitope polymorphisms of the Plasmodium falciparum circumsporozoite protein among field isolates from Sierra Leone: age-dependent haplotype distribution?

Figure 1

Sequences of P. falciparum csp haplotypes found among field isolates from two hospitals (PCMH and M-34) in Freetown, Sierra Leone, during September–October 2006 and April–May 2007. Note that only variable sites immediately after the central repeats (labeled X i.e. amino residues 308 – 317), and the regions spanning the Th2R (amino residues 326 – 342) and Th3R (amino residues 356 – 378) in the C-terminal portion of the gene are shown. Amino residue numbering is with reference to the 7G8 sequence and haplotypes labeled P-01 ~ P-30 are unique to this study. The P-17 haplotype differs from the 3D7 sequence by two silent nucleotide mutations but otherwise has an identical amino acid sequence. As shown, the "Asia-type*" refers to the Th2R*5/Th3R*1 haplotype previously shown to be predominant in Asia, but was not detected in this study.

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