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Table 2 Intra-population genetic diversity and inter-population genetic differentiation estimates of Asian and African parasites

From: T-cell epitope polymorphisms of the Plasmodium falciparum circumsporozoite protein among field isolates from Sierra Leone: age-dependent haplotype distribution?

(a) Intra-population genetic diversity parametersa

 

No. of

No. of

Haplotype

Nucleotide diversity per site (Ï€)

Population

sequences

haplotypes

diversity

Th2R

Th3R

All sites

Gambia

44

21

0.95137

0.07526

0.04343

0.02882

Sierra Leone

99

40

0.91899

0.06753

0.02926

0.02366

Vietnam

142

20

0.69693

0.02625

0.01420

0.00983

Iran

90

5

0.60275

0.01530

0.00632

0.00530

(b) Inter-population genetic differentiation parameters

Population-1

Population-2

 

FSTb

Dxyc

Dad

Kxye

Gambia

Sierra Leone

 

0.04403

0.02745

0.00121

5.68205

Gambia

Vietnam

 

0.24410

0.02557

0.00624

5.29209

Gambia

Iran

 

0.27967

0.02366

0.00662

4.89798

Sierra Leone

Vietnam

 

0.31434

0.02442

0.00768

5.05499

Sierra Leone

Iran

 

0.37256

0.02305

0.00859

4.77149

Vietnam

Iran

 

0.13221

0.00870

0.00115

1.80031

  1. aEstimates are based on pair wise analyses of 375 sequences of the C-terminal portion (207 bp) of the CSP gene spanning the Th2R and Th3R using DnaSP4.5 (21)
  2. bFST: Wright's Fixation index, which is a measure of genetic differentiation between populations (range from 0 to +1)
  3. cDxy: measures the average number of nucleotide differences per site between populations
  4. dDa: measures the number of net nucleotide substitutions per site between populations
  5. eKxy: measures the average proportions of nucleotide substitutions per site between populations