Figure 2

Loss of proliferation to HGXPRT following CD4⁺ T cell depletion. Detection of HGXPRT-specific CD4⁺ or CD8⁺ T cells from a representative patient with acute falciparum malaria; (A) before and (B) after CD4⁺ T cell depletion. Day 6 CFSE CD8⁺ and CD4⁺ T cell proliferative responses in response to (C) no antigen and (D) HGXPRT before and (E) after CD4⁺ T cell depletion. The percentages represent the proportion of CFSE low CD4⁺ and CD8⁺ T cells in culture. A similar result was observed in two other subjects.